Other notable film roles include his portrayals of the title character in Harrison's Flowers (2000); Col. Craig Harrington in Memphis Belle (1990); Whistler, the wisecracking blind techie, in Sneakers (1992); convict Ray McDeere in the legal thriller The Firm (1993); abusive husband Joe St. George in Dolores Claiborne (1995); Pierce Patchett, a millionaire involved in the seedy side of 1950s Los Angeles in L.A. Confidential (1997); Theseus, Duke of Athens, in the 1999 version of A Midsummer Night's Dream; and baseball player Eddie Cicotte in Eight Men Out (1988).
Strathairn is a character actor, appearing in supporting roles in many independent and Hollywood films. In this capacity, he has co-starred in Twisted as a psychiatrist; in The River Wild as a husband; and in Blue Car as a teacher.
Strathairn's television work also includes a wide range of roles: Moss, the bookselling nebbish on the critically acclaimed The Days and Nights of Molly Dodd; Captain Keller, the father of Helen Keller in the 2000 remake of The Miracle Worker; Capt. Frederick Benteen, a U.S. 7th Cavalry officer under General Custer's command in Son of the Morning Star; and a far-out (both figuratively and literally) televangelist in Paradise, the pilot episode for a TV series on Showtime that was not successful. Strathairn had a recurring role on the hit television drama The Sopranos. Strathairn starred in the Miami Vice episode "Out Where the Buses Don't Run."
Strathairn appeared in We Are Marshall, a 2006 film about the rebirth of Marshall University's football program after the 1970 plane crash that killed most of the team's members; and Cold Souls, starring Paul Giamatti as a fictionalized version of himself, who enlists a company's services to deep freeze his soul, directed by Sophie Barthes. In 2006 he did a campaign ad for then congressional candidate (now Senator) Kirsten Gillibrand. He reprised his role as Edward R. Murrow in a speech similar to the one from Good Night, and Good Luck, but was altered to reference Gillibrand's opponent John Sweeney.[13]
Strathairn plays the lead role in the 2007 independent film, Steel Toes, a film by David Gow (writer/co-director/producer) and Mark Adam (co-director/DOP/editor). The film is based on Gow's stage play Cherry Docs, in which Strathairn starred for its American premiere at the Wilma Theatre in Philadelphia.
He played a role in Paramount Pictures' children's film The Spiderwick Chronicles (2008) as Arthur Spiderwick. Strathairn appeared in the American Experience PBS anthology series documentary, The Trials of J. Robert Oppenheimer, a biography of the physicist. He first played Oppenheimer in the 1989 CBS TV movie Day One. He plays William Flynn, an FBI agent dealing with anarchism in 1920s New York City, in No God, No Master.
He starred as Dr. Lee Rosen on Syfy's series Alphas.[15]
In 2018-19, Strathairn appeared on the third and fourth seasons of SyFy's The Expanse[16][17] as Klaes Ashford.
In 2020, Strathairn was one of the few genuine actors in the Oscar-winner Nomadland, directed by Chloé Zhao. David appears alongside his son Tay, the first time they have acted together on screen since 1988's Eight Men Out when Tay was just eight years old.
Strathairn stars in the 2023 film Remember This, based on the stage play about the life of Polish diplomat and war hero Jan Karski who brought evidence of the Holocaust to Western governments during WW2. The film is executive-produced by Eva Anisko and directed by Jeff Hutchens and Derek Goldman.
Strathairn plays Jan Karski in the one-man play Remember This: The Lesson of Jan Karski, written by Clark Young and Derek Goldman. The play is an original production by The Laboratory for Global Performance and Politics at Georgetown University. In 2021, Strathairn garnered critical acclaim for a production of Remember This at the Chicago Shakespeare Theater.[26]
^Performance revs. by Susan Hollis Merritt, "The Birthday Party" (CSC Repertory Theatre, New York, April 17, 1988, April 12, 1988 – May 22, 1988) and Bernard Dukore, "The Birthday Party" (CSC Repertory Theatre, New York, April–May 1988), The Pinter Review 2.1 (1988): 66–70; 71–73. (Cover photograph features Strathairn in his role as Stanley.)
^1989 CSC production, HaroldPinter.org (official site), accessed August 7, 2007.
^Susan Hollis Merritt, "A Conversation with Carey Perloff, Bill Moor, Peter Riegert, Jean Stapleton, and David Strathairn: After Matinee of Mountain Language and The Birthday Party by CSC Repertory Ltd., Bruno's, New York, Nov. 12, 1989", The Pinter Review: Annual Essays 1989 (TPR) (Tampa: U of Tampa P, 1989) 59–84 (interview); cf. performance rev. by Francis Gillen, "Mountain Language, The Birthday Party" TPR 93–97. (Cover photograph features Strathairn and Stapleton in their roles as a prison Officer and the Elderly Woman in Mountain Language; his other role, the Prisoner, is the Elderly Woman's son.)
^Performance revs. by Katherine H. Burkman, "Ashes to Ashes in New York: Roundabout Theatre Company at the Gramercy Theatre, March 30, 1999" and by Susan Hollis Merritt, "Ashes to Ashes in New York: Roundabout Theatre Company, Gramercy Theatre, New York, April 3, 1999", The Pinter Review: Collected Essays 1997 and 1998 (Tampa: U of Tampa P, 1999) 154-59.