Don Henderson (1931–1997) was an English actor of stage, television and screen.

Don Henderson may also refer to:

• Don Henderson (film producer), a pseudonym used by American actor, Tom Laughlin
• Don Henderson (linesman) (born 1968), Canadian National Hockey League linesman
• Don Henderson (folk singer) (1937–1991), Australian folk singer
• Don Henderson (footballer, born 1918) (1918–2010), Australian rules footballer for Footscray in 1944
• Don Henderson (footballer, born 1930) (1930–1999), Australian rules footballer for Footscray in the 1950s
• Donald Henderson (1928–2016), known as D.A. Henderson, American physician and epidemiologist
• Donald Henderson (writer) (1905–1947), English writer.
• Donald Henderson (character) a superhero, better known as Marksman, in the Champions role-playing game; later turned into Donald "Huntsman" Hunter in the spin-off League of Champions comic books

• Donald Henderson Clarke (1887-1958), American writer and journalist

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