ECH1

ECH1
Identifiers
AliasesECH1, HPXEL, enoyl-CoA hydratase 1, peroxisomal, enoyl-CoA hydratase 1
External IDsOMIM: 600696; MGI: 1858208; GeneCards: ECH1
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
5.3.3.21↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

1891

51798

Ensembl

ENSG00000104823
ENSG00000282853

ENSMUSG00000053898

UniProt

Q13011

O35459

RefSeq (mRNA)

NM_001398

NM_016772

RefSeq (protein)

NP_001389

NP_058052

Location (UCSC)Chr 19: 38.82 – 38.83 MbChr 7: 28.52 – 28.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.[5][6]

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[6]

References

  1. ^ a b c ENSG00000282853 GRCh38: Ensembl release 89: ENSG00000104823, ENSG00000282853 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053898 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ FitzPatrick DR, Germain-Lee E, Valle D (Nov 1995). "Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase". Genomics. 27 (3): 457–66. doi:10.1006/geno.1995.1077. PMID 7558027.
  6. ^ a b "Entrez Gene: ECH1 enoyl Coenzyme A hydratase 1, peroxisomal".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q13011 (Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial) at the PDBe-KB.
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