EXOC3L2

Exocyst complex component 3-like 2 is a protein that in humans is encoded by the EXOC3L2 gene.[1][2][3][4]

The EXOC3L2 protein has been shown to interact with EXOC4[1] that is a component of the exocyst complex[5][6] involved exocytosis and more specifically in the targeting of exocytic vesicles to the cell membrane.

The exocyst complex is important for several biological processes, such as the establishment of cell polarity and regulation of cell migration.[5][7] The structure and functions of the exocyst complex are conserved from yeast to higher eukaryotes.[5][6] Endothelial cells in blood vessels express high levels of EXOC3L2 that is required for proper VEGFR-2[1] signaling so that the endothelial cells can migrate towards the growth factor VEGF-A.[8]

References

  1. ^ a b c Barkefors, I; Fuchs, PF; Heldin, J; Bergström, T; Forsberg-Nilsson, K; Kreuger, J (2011). "Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells". The Journal of Biological Chemistry. 286 (27): 24189–99. doi:10.1074/jbc.M110.212209. PMC 3129200. PMID 21566143.
  2. ^ EntrezGene 90332
  3. ^ Olgiati, P; Politis, AM; Papadimitriou, GN; De Ronchi, D; Serretti, A (2011). "Genetics of late-onset Alzheimer's disease: Update from the alzgene database and analysis of shared pathways". International Journal of Alzheimer's Disease. 2011 832379. doi:10.4061/2011/832379. PMC 3235576. PMID 22191060.
  4. ^ Belbin, O; Carrasquillo, MM; Crump, M; Culley, OJ; Hunter, TA; Ma, L; Bisceglio, G; Zou, F; Allen, M (2011). "Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease". Human Genetics. 129 (3): 273–82. doi:10.1007/s00439-010-0924-2. PMC 3036835. PMID 21132329.
  5. ^ a b c Liu, J; Guo, W (2011). "The exocyst complex in exocytosis and cell migration". Protoplasma. 249 (3): 587–597. doi:10.1007/s00709-011-0330-1. PMID 21997494. S2CID 11946932.
  6. ^ a b Munson, M; Novick, P (2006). "The exocyst defrocked, a framework of rods revealed". Nature Structural & Molecular Biology. 13 (7): 577–81. doi:10.1038/nsmb1097. PMID 16826234. S2CID 26645238.
  7. ^ Thapa, N; Sun, Y; Schramp, M; Choi, S; Ling, K; Anderson, RA (2012). "Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells". Developmental Cell. 22 (1): 116–30. doi:10.1016/j.devcel.2011.10.030. PMC 3266520. PMID 22264730.
  8. ^ Carmeliet, P; Jain, RK (2011). "Molecular mechanisms and clinical applications of angiogenesis". Nature. 473 (7347): 298–307. Bibcode:2011Natur.473..298C. doi:10.1038/nature10144. PMC 4049445. PMID 21593862.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.