Sauerbrey was born in Baltimore, Maryland, the only child of Ethel, a secretary/stenographer, and Edgar Richmond, a steelworker for Bethlehem Steel at Sparrows Point.[4] She is a 1955 graduate of Towson High School and a 1959 graduate of Western Maryland College, and was a teacher before entering politics.[5] In 1959, she married Wilmer J.E. Sauerbrey,[4] who is credited with having introduced her to conservative politics.[6]
From 1978 to 1994, she was a Republican member of the Maryland House of Delegates, and served as minority leader from 1986 to 1994. Her committee assignments included the Appropriations Committee; Subcommittee on Education and Transportation; Ways and Means and Economic Matters.
Sauerbrey ran unsuccessfully for Governor of Maryland twice, in 1994 and 1998. She was defeated by Democrat Parris Glendening both times, the first time by a very narrow margin. The 1994 election was in doubt as charges of voter fraud led to a lawsuit by the Sauerbrey campaign to overturn the election, which was ultimately unsuccessful.
In January 2006, while the Senate was recessed, President Bush appointed Sauerbrey as Assistant Secretary of State for Population, Refugees, and Migration. It was reported then that this and other such appointments would end at the conclusion of the congressional session in January 2007.[9]
In a January 15, 2007, hearing before the Senate Judiciary Committee, Democratic lawmakers and advocates for refugees called for increased help for fleeing Iraqis. Sauerbrey said a UN-predicted wave of refugees did not occur right after the U.S.-led invasion of Iraq and was instead occurring at that present time.[10]
In November 2020, amid attempts to overturn the U.S. presidential election, Sauerbrey expressed no regrets about challenging her 1994 election outcome, saying, "I think when you have a pretty good indication that the election is rigged, you should fight". Sauerbrey also questioned the transparency, accuracy, and timeliness involved with counting mail-in ballots.[16]