On 7 July 2016, he signed a five-year contract with French club Lyon.[4] He scored his first goal for the club in a 1–1 draw with Bordeaux.
Zenit Saint Petersburg
On 31 July 2017, Mammana signed a five-year contract with the Russian club FC Zenit Saint Petersburg.[5] On 11 March 2018 in a game against FC Rostov he suffered an anterior cruciate ligament injury which forced him to miss almost six months of games, that time period included the 2018 FIFA World Cup.[6] Upon his recovery, he could not get back into the lineup in the 2018–19 season. On 6 October 2019, he suffered another ligament injury in a game against FC Ural Yekaterinburg[7] and missed 9 more months of games, before returning in the last game of the 2019–20 season. In June 2021, after returning from Sochi loan, he was sent by Zenit to train with the second team, FC Zenit-2 Saint Petersburg.[8] On 7 January 2022, his contract with Zenit was terminated by mutual consent.[9]
Loan to Sochi
On 7 August 2020, he joined PFC Sochi on loan for the 2020–21 season.[10] On 19 July 2021, Mammana returned to Sochi on loan for the 2021–22 season.[11]
Return to River Plate
On 10 January 2022, Mammana rescinded his contract with Zenit, and returned to River Plate.[12][13][14]
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