Exomer

Exomer is a heterotetrameric protein complex similar to COPI and other adaptins.[1][2] It was first described in the yeast Saccharomyces cerevisiae.[3] Exomer is a cargo adaptor important in transporting molecules from the Golgi apparatus toward the cell membrane. The vesicles it is found on are different from COPI vesicles in that they do not appear to have a "coat" or "scaffold" around them.[1]

An overview of the cellular localization of exomer and other cargo adaptors is shown here. Exomer binds to 2 molecules of ADP-ribosylation factor 1 (Arf1) as shown in this figure. A hinge region of exomer is thought to be important for forming to a highly curved membrane vesicle[1] as shown in this figure. The steps of assembly of exomer on a Golgi membrane are shown in this figure.[4]

See also

References

  1. ^ a b c Paczkowski JE, Richardson BC, Fromme JC (July 2015). "Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis". Trends in Cell Biology. 25 (7): 408–16. doi:10.1016/j.tcb.2015.02.005. PMC 4475447. PMID 25795254.
  2. ^ Roncero C, Sanchex-Diaz A, Valdivieso MH (2016). "Chitin Synthesis and Fungal Cell Morphogenesis". In Hoffmeister D (ed.). Biochemistry and Molecular Biology. Springer. pp. 167–190. ISBN 978-3-319-27790-5.
  3. ^ Wang CW, Hamamoto S, Orci L, Schekman R (September 2006). "Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast". The Journal of Cell Biology. 174 (7): 973–83. doi:10.1083/jcb.200605106. PMC 2064389. PMID 17000877.
  4. ^ Huranova M, Muruganandam G, Weiss M, Spang A (2016). "Dynamic assembly of the exomer secretory vesicle cargo adaptor subunits". EMBO Reports. 17 (2): 202–19. doi:10.15252/embr.201540795. PMC 5290816. PMID 26742961.

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