FENDRR
| FENDRR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21, FOXF1 adjacent non-coding developmental regulatory RNA, FOXF1AS1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614975; GeneCards: FENDRR | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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FOXF1 adjacent non-coding developmental regulatory RNA is a long non-coding RNA that in humans is encoded by the FENDRR gene.[3]
Function
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000268388 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: FOXF1 adjacent non-coding developmental regulatory RNA". Retrieved 2016-11-10.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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