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FRAT2
Identifiers
Aliases	FRAT2, WNT signaling pathway regulator, FRAT-2, FRAT regulator of WNT signaling pathway 2
External IDs	OMIM: 605006; MGI: 2673967; GeneCards: FRAT2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,334,729 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,836,571 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; secondary oocyte; ; mucosa of transverse colon; ; bone marrow; ; trabecular bone; ; jejunal mucosa; ; duodenum; ; palpebral conjunctiva;
	Top expressed in
	spermatid; ; left colon; ; granulocyte; ; ventricular zone; ; extensor digitorum longus muscle; ; fetal liver hematopoietic progenitor cell; ; vastus lateralis muscle; ; ganglionic eminence; ; knee joint; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	cytosol; cellular component; cytoplasm;
Biological process	multicellular organism development; cell population proliferation; Wnt signaling pathway; beta-catenin destruction complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23401
	212398
	ENSG00000181274
	ENSMUSG00000047604
	O75474
	Q8K025
	NM_012083
	NM_177603
	NP_036215
	NP_808271
	Wikidata
View/Edit Human	View/Edit Mouse

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.^[5]^[6]^[7]

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181274 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047604 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432. S2CID 17951152.
^ Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732.
^ ^a ^b "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation". Structure. 9 (12): 1143–52. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene. 291 (1–2): 17–27. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stoothoff WH, Cho JH, McDonald RP, Johnson GV (2005). "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation". J. Biol. Chem. 280 (1): 270–6. doi:10.1074/jbc.M410061200. PMID 15522877.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181274 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047604 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9635432-5] Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432. S2CID 17951152.

[pmid11237732-6] Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732.

[entrez-7] "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2".

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FRAT2

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