• Both countries have established diplomatic relations on 28 October 1975.^[21]
• Guyana is covered through the Botswana Mission in New York City.^[22]
• Both countries are full members of Commonwealth of Nations.

• Both countries have established diplomatic relations on 13 December 1994.^[21]
• Both countries are full members of Commonwealth of Nations.
• Guyana is accredited to Namibia from its high commission in Pretoria, South Africa.
• Namibia is accredited to Guyana from its Permanent Mission to the United Nations in New York City.

• Both countries established diplomatic relations on 4 November 1994.^[23]
• South Africa is represented in Guyana through its High Commission in Kingston, Jamaica.^[23]

• Both countries have established diplomatic relations on 6 October 1972.^[21]
• Argentina has an embassy in Georgetown, Guyana.^[24]
• Both countries are full members of Organization of American States and Union of South American Nations.

The relations between Guyana and Barbados had its genesis to a time when both Guyana (then British Guiana) and Barbados were both British colonies. Shortly after Great Britain secured British Guiana from the Dutch, waves of migrants were encouraged to move and settle in Guyana. Barbados was one such location where large numbers of migrants came from. Through time Barbados and Guyana have both supported each other. With the move towards independence in the region Guyana was seen as the breadbasket of the wider Caribbean which led to yet more waves of Barbadians seeking to move to Guyana for better opportunities.

Relations have been rocky, during the 1990s, immigration became contentious for Guyanese persons to Barbados. Such terms as the "Guyanese bench" in the immigration area of the Barbados Sir Grantley Adams International Airport have tested both states at times. The two nations continue their cooperation through the Caribbean Community (CARICOM) and work towards building and maintaining good relations between their nationals. Both nations also attempt to maintain open communications at high levels of both Governments.

More recently the Guyanese Government has extended an offer to Barbadians.^[25][26] The Guyanese government has offered to put in place an economically favourable regime towards any Barbadians that wish to relocate to Guyana and contribute towards that nation's goals in agricultural investment.^[27] The announcement was made in the final days of the Owen Arthur administration by MP member Mia Mottley.

In the early 1990s the Prime Minister of Trinidad and Tobago, Patrick Manning pitched an initiative for Barbados, Guyana and Trinidad and Tobago to enter into some form of political union or political association. This initiative was short lived and didn't proceed following the Democratic Labour Party's defeat during the 1994 elections.

Brazil–Guyana relations have traditionally been close. Brazil has provided military assistance to Guyana in the form of war fare training and logistics. Bilateral relations between the countries have recently increased, as a result of Brazil's new South-South foreign policy aimed to strengthen South American integration.

During a state visit by Brazilian President Luiz Inácio Lula da Silva to Georgetown on 2 March 2007, the governments of Guyana and Brazil signed several cooperation agreements and announced plans to boost trade between the two countries.

Canada started relations with Guyana in 1964^[28] with the construction of the Commission of Canada in Georgetown. In 1966 it became a Canadian High Commission. There is a Guyanese High Commission in Ottawa and a Guyanese Consulate in Toronto.

Canada and Guyana have strong ties through the Commonwealth of Nations. There is an estimated 200,000 Guyanese living in Canada. The Royal Canadian Mounted Police and the Guyanese police work closely to help with drug, and human smuggling.

Guyana's largest import from Canada is machinery (CAD $13 mil), and export is precious metals (CAD$482 mil).^[29] Food exports generally cater to Canada's Guyanese diaspora population.^[30]

Dominica and Guyana have established diplomatic relations on 3 November 1978.^[31]

• Guyana has a High Commission in Roseau.^[32]

• Guyana is accredited to Mexico from its embassy in Washington, D.C., United States.^[33]
• Mexico has an embassy in Georgetown.^[34]

• Both countries established diplomatic relations on 25 November 1975.^[6]
• Both countries are full members of the Organization of American States, and of the Caribbean Community.
• There is an ongoing territorial dispute between Guyana and Suriname regarding the Tigri Area.

Guyana and Trinidad and Tobago have had historically close ties due to their shared culture, history, dominion under the British empire, demographics and religion. Both Countries have a substantial population of Hindus from indentured servitude from India along with a large African population from Africa. Both countries are a part of the Commonwealth of Nations and CARICOM. Trinidad was the largest forgiver of debt in the 1990s Paris Club Agreement to Guyana, forgiving Hundred of Millions of Debt. A substantial number of Guyanese people live in Trinidad and Tobago. In recent years, relations between the two countries warmed with Guyana establishing its First Diplomatic Mission in Port of Spain in 2017. In 2018, they signed a Memorandum of Understanding on Energy Cooperation.

U.S. policy toward The Co-operative Republic of Guyana seeks to develop robust, sustainable democratic institutions, laws, and political practices; support economic growth and development; and promote stability and security. During the last years of his administration, President Hoyte sought to improve relations with the United States as part of a decision to move his country toward genuine political nonalignment. Relations also were improved by Hoyte's efforts to respect human rights, invite international observers for the 1992 elections, and reform electoral laws. The United States also welcomed the Hoyte government's economic reform and efforts, which stimulated investment and growth. The 1992 democratic elections and Guyana's reaffirmation of sound economic policies and respect for human rights have placed U.S.-Guyanese relations on an excellent footing. Under successive PPP governments, the United States and Guyana continued to improve relations. President Cheddi Jagan was committed to democracy, adopted more free market policies, and pursued sustainable development for Guyana's environment.

• Guyana has an embassy in Washington, DC and a consulate-general in New York City.
• United States has an embassy in Georgetown.^[35]

• Both countries established diplomatic relations on 3 June 1985.^[21]
• Both countries are full members of Organization of American States and Union of South American Nations.

Venezuela claimed more than half of the territory of the British colony of Guyana at the time of the Latin American wars of independence, a dispute that was settled by arbitration in 1899. In 1962 Venezuela declared that it would no longer abide by the arbitration decision, which ceded mineral-rich territory in the Orinoco basin to Guyana. The area is called "Guayana Esequiba" by Venezuela. A border commission was set up in 1966 with representatives from Guyana, Venezuela and Great Britain, but failed to reach agreement. Venezuela vetoed Guyana's bid to become a member of the Organization of American States (OAS) in 1967. In 1969 Venezuela backed an abortive uprising in the disputed area.

Under intense diplomatic pressure, Venezuela agreed in 1970 to a 12-year moratorium on the dispute with the Protocol of Port-of-Spain. In 1981, Venezuela refused to renew the protocol. However, with changes to the governments of both countries relations improved, to the extent that in 1990 Venezuela sponsored Guyana's bid for OAS membership in 1990.^[36][37]

Bilateral relations are good and progress on the economic side.^[38] In 2022 exports from Guyana to China reached sum $1 billion.^[39] Currently Chinese state owned companies are working to construct the largest bridge in Guyana which will span the Demerara River.^[40]

Relations between India and Guyana ever since the independence of Guyana in May 1966 have been cordial.^[41] The cordiality in the relation remains unaffected with changes in governments either in India or in Guyana. Late Shrimati Indira Gandhi, the then Prime Minister of India, visited Guyana in 1968, late Dr. Shankar Dayal Sharma, the then Vice President of India visited Guyana in 1988 and Shri Bhairon Singh Shekhawat, the then Vice President of India came on a state visit to Guyana in 2006.^[41]

The cooperation between the two countries in sharing developmental experience is mainly routed through Indian Technical & Economic Cooperation (ITEC) under which forty scholarships are granted every year in various courses. Besides, some experts are also deputed to Guyana from time to time on request in specified areas of activity. Several other scholarships are also available to Guyanese to pursue long-term courses, to get acquainted with India and to learn Hindi language in India.

India has offered credit facilities to Guyana for use in mutually accepted designated fields, agriculture and information technology, being two of these. Indian companies have also expressed interest in bio fuel, energy, minerals and pharmaceuticals. Total trade turn over remains low, though the trend is positive.

Indian Cultural Centre in Georgetown was established in 1972 with the objective of strengthening cultural relations and mutual understanding between India and Guyana and their peoples. The Centre runs regular classes in Yoga and Dance (Kathak). The centre has a well equipped Auditorium where cultural events are organised on a regular basis. The teachers and students of ICC participate in events by the local community on various occasions round the year. The centre has a library with books/publications on history, literature, art, culture, mythology and works of eminent scholars and authors.

An important cultural connection between India and Guyana is cricket. With the advent of the Indian Premier League, many Guyanese players were contracted to play in India.^[41]

• Guyana has an embassy in Doha.
• Qatar has an embassy in Georgetown.

The Republic of Guyana and The Republic of Korea established diplomatic relations on 1968-06-13.^[42]

• Both countries established diplomatic relations on 25 February 2003.^[43]
• Croatia is represented in Guyana through its Permanent Mission in New York City.^[44]

• Both countries established diplomatic relation on 11 May 2011.^[45]
• Cyprus is represented in Guyana by its embassy in Brasília, Brazil.^[46]
• Both countries are full members of Commonwealth of Nations.

• Both countries established diplomatic relations on 16 November 1979.^[21]
• Denmark is represented in Guyana, through its embassy in Brasília.^[47]
• Guyana is represented in Denmark, through its embassy in Brussels.

• Both countries established diplomatic relations on 2 April 1979.^[21]
• Guyana is represented in Finland by their embassy in Brussels, Belgium.
• Finland also has an honorary consulate general in Georgetown.

• Both countries established diplomatic relations on 22 June 1967.^[21]
• France is represented in Guyana through its embassy in Paramaribo, Suriname.^[48]
• France has an honorary consulate in Guyana.^[49]
• Both countries have passed a number of bilateral treaties.^[50]

• Both countries established diplomatic relations in 1966.^[51]
• Germany is represented in Guyana through its embassy in Port of Spain, Trinidad and Tobago.^[52]

• Both countries established diplomatic relations on 23 April 2012.^[53]
• Bilateral political consultations between the Foreign Agencies cooperation is ongoing between both countries in political, legal, cultural, trade and economic relations. Cooperation concerning the academic exchanges is successfully implemented.^[53]

• Both countries established diplomatic relations on 14 May 1979.^[21]
• Greece is represented in Guyana by its embassy in Caracas, Venezuela.^[54]
• Greece has provided Guyana with development aid in the past.^[54]

• Both countries established diplomatic relations on 15 May 1970.^[55]
• Netherlands is represented in Guyana by its embassy in Paramaribo, Suriname
• Suriname is represented in the Netherlands by its embassy in Brussels, Belgium

• Both countries established diplomatic relations on 17 December 1970.
• Guyana is represented in Russia by its High Commission in London, United Kingdom.
• Russia is represented in Guyana by its embassy in Georgetown, Guyana.

• Both countries established diplomatic relations on 5 November 1968.^[56]
• Serbia is represented in Guyana through its embassy in Washington, D.C.^[57]

Guyana established diplomatic relations with the United Kingdom on the 26 May 1966.^[58]

• Guyana maintains a high commission in London.^[58]
• The United Kingdom is accredited to Guyana through its high commission in Georgetown.^[59]

The UK governed Guyana from 1803 to 1966, when Guyana achieved full independence.

Both countries share common membership of the Atlantic co-operation pact,^[60] the Commonwealth, and the World Trade Organization, as well as the CARIFORUM–UK Economic Partnership Agreement.^[61] Bilaterally the two countries have an Investment Agreement.^[62]

• Australia is represented in Guyana through its embassy in Port of Spain, Trinidad and Tobago.^[63]
• Both countries are members of the Commonwealth of Nations.^[64]