It was announced on 22 April 2021 by Prime Minister of BelizeJohn Briceno that she was nominated to be the next Governor-General of Belize following the retirement of Sir Colville Young.[8] She is the third Governor-General and the second woman appointed to the role.
Upon the death of Queen Elizabeth II in September 2022, Tzalam became the first governor-general of Belize to have served under two monarchs. She said that the Queen "was a much loved and respected figure across the globe", who "was known for her sense of duty and her devotion to a life of service".[13] Tzalam also represented Belize at the Queen's state funeral in the United Kingdom.[14] Alongside Minister Francis Fonseca she represented Belize at the Coronation of King Charles III in 2023.[15]