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GAS6

GAS6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGAS6, AXLLG, AXSF, growth arrest specific 6
External IDsOMIM: 600441; MGI: 95660; HomoloGene: 638; GeneCards: GAS6; OMA:GAS6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143946
NM_000820
NM_001143945

NM_019521

RefSeq (protein)

NP_000811

NP_062394

Location (UCSC)Chr 13: 113.82 – 113.86 MbChr 8: 13.52 – 13.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

Function

Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.[5]

Interactions

Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.[6][7]

The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum. The action of vitamin K is essential on GAS6 function.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183087Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031451Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GAS6 growth arrest-specific 6".
  6. ^ Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (Apr 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659.
  7. ^ Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (Nov 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948.
  8. ^ Bellido-Martín L, de Frutos PG (2008). "Vitamin K-dependent actions of Gas6". Vitamins and Hormones. 78: 185–209. doi:10.1016/S0083-6729(07)00009-X. hdl:10261/37140. ISBN 978-0-12-374113-4. PMID 18374195.

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