GATAD2B

GATAD2B

Identifiers

GATAD2B, MRD18, P66beta, p68, GATA zinc finger domain containing 2B, GANDS

External IDs

OMIM: 614998; MGI: 2443225; GeneCards: GATAD2B

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	153,789,030 bp^[1]
Band	1q21.3	End	153,923,360 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F1	Start	90,200,485 bp^[2]
Band	3\|3 F1	End	90,270,714 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

epithelium of colon

corpus callosum

bone marrow cell

skeletal muscle tissue

blood

tonsil

ganglionic eminence

sural nerve

ventricular zone

cerebellum

Top expressed in

secondary oocyte

zygote

ascending aorta

aortic valve

Rostral migratory stream

primary oocyte

supraoptic nucleus

genital tubercle

tail of embryo

cumulus cell

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleosomal DNA binding sequence-specific DNA binding zinc ion binding protein binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nuclear speck nucleus nucleoplasm NuRD complex protein-containing complex
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


57459


229542


ENSG00000143614 ENSG00000261992


ENSMUSG00000042390


Q8WXI9


Q8VHR5

RefSeq (mRNA)


NM_020699


NM_139304 NM_001379655 NM_001379656 NM_001379657

RefSeq (protein)


NP_065750


NP_647465 NP_001366584 NP_001366585 NP_001366586

Location (UCSC)

Chr 1: 153.79 – 153.92 Mb

Chr 3: 90.2 – 90.27 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.^[5]^[6]^[7]

Interactions

GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2,^[6]^[8] MBD3,^[6]^[8] RBBP7^[6] and RBBP4.^[6]

References

^ ^a ^b ^c ENSG00000261992 GRCh38: Ensembl release 89: ENSG00000143614, ENSG00000261992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042390 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461. S2CID 263221761.
^ ^a ^b ^c ^d ^e Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (Dec 2001). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol Cell Biol. 22 (2): 536–46. doi:10.1128/MCB.22.2.536-546.2002. PMC 139742. PMID 11756549.
^ "Entrez Gene: GATAD2B GATA zinc finger domain containing 2B".
^ ^a ^b Brackertz M, Boeke Joern, Zhang Ru, Renkawitz Rainer (Oct 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43). United States: 40958–66. doi:10.1074/jbc.M207467200. ISSN 0021-9258. PMID 12183469.

Further reading

Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Brackertz M, Gong Z, Leers J, Renkawitz R (2006). "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction". Nucleic Acids Res. 34 (2): 397–406. doi:10.1093/nar/gkj437. PMC 1331983. PMID 16415179.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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