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GBA Identifiers Aliases GBA, GBA1, GCB, GLUC, glucosylceramidase beta, Glucocerebrosidase External IDs OMIM: 606463; MGI: 95665; GeneCards: GBA Available...

disease. It is taken orally. GCase is a lysosomal enzyme encoded by the gene GBA1. Loss-of-function mutations in this gene are thought to promote α-synuclein...

with nearly half of recessive, early-onset monogenic PD. Mutations in the GBA1 gene are associated with cognitive decline. The limited heritability of Parkinson's...

rare but highly penetrant, and CHCHD2. LRRK2 (PARK8, DARDARIN) and GBA (GBA1) are pathogenic but have variable penetrance. Dominant genes associated with...

HGNC:26616; Q8NB37 6102 GATD3 HGNC:1273; P0DPI2 6103 GATM HGNC:4175; P50440 6104 GBA1 HGNC:4177; P04062 6105 GBA2 HGNC:18986; Q9HCG7 6106 GBA3 HGNC:19069; Q9H227...

Gaucher disease is caused by mutations in GBA1, which encodes the lysosomal catalyst glucocerebrosidase (GCase). GBA1 transformations drive broad gathering...

States Fredrick Van Goor United States Thomas Gasser Germany "for identifying GBA1 and LRRK2 as risk genes for Parkinson's disease, implicating autophagy and...

(AAD-2004) – microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor [166] CTx-GBA1 – gene transference [167] Cu(II)ATSM (copper(II)-ATSM; Cu-ATSM) – neuron...

genome was fully sequenced (Genbank accession numbers CM002271- plasmid pGBA1 CM002272). Streptomyces poriferorum (type strain P01-B04T), an Actinomycetota...