GCN1

GCN1

Identifiers

GCN1, GCN1L, PRIC295, GCN1L1, eIF2 alpha kinase activator homolog, GCN1 activator of EIF2AK4

External IDs

OMIM: 605614; MGI: 2444248; GeneCards: GCN1

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q24.23	Start	120,127,202 bp^[1]
Band	12q24.23	End	120,194,715 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	115,703,313 bp^[2]
Band	5\|5 F	End	115,760,713 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

tendon of biceps brachii

sural nerve

pylorus

gastrocnemius muscle

cardia

stromal cell of endometrium

right lobe of thyroid gland

nipple

granulocyte

Top expressed in

neural layer of retina

Rostral migratory stream

ventricular zone

lumbar subsegment of spinal cord

spermatid

muscle of thigh

yolk sac

superior frontal gyrus

secondary oocyte

primary visual cortex

More reference expression data


More reference expression data

Gene ontology
Molecular function	ribosome binding translation factor activity, RNA binding protein kinase binding protein kinase regulator activity RNA binding cadherin binding
Cellular component	polysome ribosome membrane cytoplasm cytosol
Biological process	positive regulation of transcription from RNA polymerase II promoter in response to stress positive regulation of kinase activity cellular response to stress cellular response to amino acid starvation regulation of protein kinase activity cellular response to leucine starvation regulation of translation protein biosynthesis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10985


231659


ENSG00000089154


ENSMUSG00000041638


Q92616


E9PVA8

RefSeq (mRNA)


NM_006836


NM_172719

RefSeq (protein)


NP_006827


NP_766307

Location (UCSC)

Chr 12: 120.13 – 120.19 Mb

Chr 5: 115.7 – 115.76 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Translational activator GCN1 is a protein that in humans is encoded by the GCN1 gene (previously GCN1L1).^[5]^[6]

Interactions

GCN1 has been shown to interact with CDC5L.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089154 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041638 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K, Hinnebusch AG (August 1997). "Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2". Mol Cell Biol. 17 (8): 4474–89. doi:10.1128/mcb.17.8.4474. PMC 232301. PMID 9234705.
^ "Entrez Gene: GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)".
^ Ajuh P, Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23). ENGLAND: 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi:10.1038/nature04569. PMID 16541075.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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