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GTPBP1
Identifiers
Aliases	GTPBP1, GP-1, GP1, HSPC018, GTP binding protein 1
External IDs	OMIM: 602245; MGI: 109443; GeneCards: GTPBP1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,738,299 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,605,680 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastric mucosa; ; ventricular zone; ; ganglionic eminence; ; right uterine tube; ; left lobe of thyroid gland; ; skin of leg; ; popliteal artery; ; tibial arteries; ; left ovary;
	Top expressed in
	neural layer of retina; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; ventricular zone; ; thymus; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell; ; zygote; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; RNA binding; GTPase activity; translation elongation factor activity;
Cellular component	cytoplasm; cytoplasmic exosome (RNase complex); cytosol; membrane;
Biological process	positive regulation of mRNA catabolic process; immune response; signal transduction; GTP metabolic process; translational elongation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9567
	14904
	ENSG00000100226
	ENSMUSG00000042535
	O00178
	O08582
	NM_004286
	NM_013818
	NP_004277
	NP_038846
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.^[5]^[6]

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100226 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042535 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.
^ ^a ^b "Entrez Gene: GTPBP1 GTP binding protein 1".

Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein". Biochem. J. 336 (2): 381–6. doi:10.1042/bj3360381. PMC 1219882. PMID 9820815.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1". Mol. Cell. Biol. 20 (17): 6195–200. doi:10.1128/MCB.20.17.6195-6200.2000. PMC 86094. PMID 10938096.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100226 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042535 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9070279-5] Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.

[entrez-6] "Entrez Gene: GTPBP1 GTP binding protein 1".

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GTPBP1

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