Findings additionally suggest that GALP could play a function in energy metabolism due to its ability to maintain continual activation of the sympathetic nervous system (SNS) via thermogenesis, which refers to the production of heat within living organisms.[10] In addition, the administration of GALP directly into the brain leads to a reduction in the secretion of thyroid-stimulating hormone (TSH), which indicates the involvement of GALP in the neuroendocrine regulation of the hypothalamic-pituitary-thyroid (HPT) axis, and further adding to the evidence of the role of GALP in energy homeostasis.[11]
Notes
^Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S (February 2003). "Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis". Neuroendocrinology. 77 (2): 125–31. doi:10.1159/000068648. PMID12624534. S2CID8589263.
^Kageyama H, Takenoya F, Kita T, Hori T, Guan JL, Shioda S (March 2005). "Galanin-like peptide in the brain: effects on feeding, energy metabolism and reproduction". Regulatory Peptides. 126 (1–2): 21–6. doi:10.1016/j.regpep.2004.08.029. PMID15620409. S2CID26597732.
^Kageyama H, Takenoya F, Hori Y, Yoshida T, Shioda S (January 2008). "Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus". Regulatory Peptides. 145 (1–3): 165–8. doi:10.1016/j.regpep.2007.08.019. PMID17916390. S2CID40659877.
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