Cherilus was the only redshirt freshman to start for the Eagles.[3] He helped the Eagles to average 385.4 yards per game in total offense.[4]
2005 season
He started all 12 contests at right tackle during 2005 season.[3] He worked well with right guard Josh Beekman, as the pair helped the Eagles record 387.75 total yards per game.[5]
2006 season
In 2006, Cherilus started in all 13 games at right tackle and paved the way for seven 100-yard rushing games and a collective 1,424 rushing yards by L. V. Whitworth and Andre Callender.[3] He helped the team average 114.5 yards per game on the ground and 355.6 yards in total offense.[6] He played at the 2006 Meineke Car Care Bowl win over Navy.[7]
2007 season
He was named all-Atlantic Coast Conference (ACC) second-team selection and recipient of the team’s Unsung Hero Award, Cherilus started 14 games at left tackle, helping BC rank seventh in the nation with an average of 323.9 yards per game passing, he registered 77 knockdowns with twelve touchdown-resulting blocks, finishing with a 78.0 percent grade for blocking consistency and also helped hold opponents to only 61 tackles-for-loss (fifth in the nation) and 22 sacks.[citation needed]
The Lions selected Cherilus in the first round with the 17th overall pick in the 2008 NFL Draft.[12] As a rookie, Cherilus became a starter in the offensive line in his third game in the league replacing George Foster, and held that position for most of the 2008 season. As a rookie, he appeared in 16 games and started 13.[13] In the 2009 season, he started all of the regular season games but Week 5.[14] In the 2010 season, he started the first 12 games before suffering a season-ending knee injury.[15][16] In the 2011 season, he started in all of the regular season games but Week 2. In addition, he started in the Lions' playoff game.[17] In the 2012 season, he started in all 16 regular season games.[18]
Indianapolis Colts
On March 12, 2013, Cherilus signed a five-year, $35 million with the Indianapolis Colts.[19] Upon signing his contract with the Colts, Cherilus was the highest paid right tackle in the NFL at that time.[20] He played the right tackle position opposite left tackle Anthony Castonzo.[21] In 2013, he started all 16 games and started in the Colts' two postseason games.[22] In 2014, Cherilus started 13 games, including his 100th career start in week 15. He missed the final two weeks of the regular season due to injury, and was placed on season-ending injured reserve on December 31, which is New Year's Eve.[23][24]
On July 26, 2015, Cherilus was released by the Colts, two years into his five-year contract, having started 29 games.[25]
Tampa Bay Buccaneers
On August 17, 2015, Cherilus signed a two-year contract with the Tampa Bay Buccaneers.[26] During the 2015 season with the Buccaneers, Cherilus started in all 13 games he played for the team.[27] In the 2016 season, he played in 15 games, starting in three.[28]
On March 16, 2017, Cherilus announced his retirement from the NFL.[29]
On August 18, 2024, Cherilus was arrested "after he allegedly urinated on another passenger during a cross-Atlantic flight."[32] His actions caused the Delta Air Lines flight he was on, which had departed Boston for Dublin, to return to Boston, where he was arrested by Massachusetts State Police.[33] In a statement issued the following day, Cherilus noted, in part, that he "took a sleeping medication that I don’t normally use, which resulted in behavior that is not representative of my character".[33]