From 1990 to 2008, Vashadze engaged in private business and lived mostly in Moscow and New York.[citation needed] He returned to Georgia in 2005. In February 2008, he was appointed Deputy to the Foreign Minister David Bakradze whom he succeeded as an acting minister in April 2008.[citation needed] He continued to work as Deputy Foreign Minister and became Minister for Foreign Affairs of Georgia in December 2008, succeeding Ekaterine Tkeshelashvili.[citation needed] In October 2012, he was succeeded by Maia Panjikidze.[citation needed]
In July 2018 Vashadze was nominated as a presidential candidate for 2018 Georgian presidential election by United National Movement and 9 other opposition parties. In the first round of the election, his opponent Salome Zurabishvili won just one percentage point ahead of Vashadze.[1] In his presidential campaign, Vashadze signalled his intention to use the presidency’s limited powers to send a vocal message of integration with NATO and the European Union.[2] He also promised to reduce bureaucracy and took a strong stance against the legalization of cannabis.[3]
On 24 March 2019 after Mikheil Saakashvili stepped down as chairman of the United National Movement, he was nominated by the former chairman and won the following leadership election unopposed. He served as chairman until 15 December 2020, when he left the party.[citation needed]
Vashadze held dual citizenship of Georgia and Russia. During an interview with Russian newspaper Kommersant in December 2008, Vashadze stated that he was not going to refuse the Russian citizenship.[6] His refusal was heavily criticized by Georgian opposition.[7]Semyon Bagdasarov, a deputy of the Russian State Duma, suggested to strip Vashadze of his Russian citizenship on account of his being "anti-Russian", but the parliament quickly dismissed the proposal as illegal. Following this incident, Vashadze renounced his Russian citizenship.[8][9]