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Guy Dodson

Guy Dodson
Born
George Guy Dodson

(1937-01-13)13 January 1937
Palmerston North, New Zealand
Died24 December 2012(2012-12-24) (aged 75)
York, England
Alma materUniversity of New Zealand (BSc, PhD)
SpouseEleanor Dodson[1]
Children4[1]
Awards
Scientific career
FieldsX-ray crystallography
Institutions
Website

George Guy Dodson FRS FMedSci (13 January 1937 – 24 December 2012), was a British biochemist who specialised in protein crystallography at the University of York.[2][3][4][5][6][7][8][9]

Education

Dodson graduated from the University of New Zealand where he was awarded a Bachelor of Science and Doctor of Philosophy degrees. His doctoral thesis, completed in 1961, was titled An X-ray analysis of an alkaloid and some investigation into nickel bis-salicylaldahyde triethylene tetramine.[10]

Career

Dodson did postdoctoral research with Dorothy Hodgkin at the University of Oxford.[11][12][13][14] He devised along with Hodgkin, very intricate experimental, crystallographic and computer techniques that led to the final solution of the structure of insulin. Dodson was head of the structural biology laboratories at the University of York and National Institute for Medical Research, London. During his career he collaborated with many scientists[9] including Dale Wigley, Gideon Davies,[4] Andrzej Brzozowski,[15] Leo Brady[16] and Max Perutz.[17]

Awards and honours

Dodson was elected a Fellow of the Royal Society (FRS)[18] in 1994. His nomination reads

Guy Dodson's major researches have been concerned with the Xray analysis of a variety of crystalline proteins many now being carried out with increasing speed and accuracy through the use of synchrotron radiation. His most considerable work, on insulin, extends from his part in the first solution of the 2 zinc insulin crystal structure to the refinement of the atomic parameters of both protein and water moledules at 1.5A resolution. He has recently explored remarkable conformational variations of the insulin molecule under different conditions, which give rise to three different hexamers, dimers at different pH and a monomeric despentapeptide insulin. He is at present investigating structure activity relations of genetically engineered varieties of insulin. Other systems he has studied include a series of bacterial ribonucleases and the T state of haemoglobin as seen in the partially liganded T alpha oxy beta deoxy, T alpha met beta met and T alpha deoxy beta deoxy human haemoglobins, crystallised from polyethyleneglycol. It is characteristic of him that he has created a laboratory to which protein crystals are brought from all over the world and their structures solved.[19]

Dodson was also a Foreign Member of the Indian National Science Academy (ForMemINSA) and the Academy of Medical Sciences (FMedSci).

He was a recipient of the RSC Structural Chemistry Award in 1991.

Personal life

Dodson was married to the scientist Eleanor Dodson with whom he had four children.[1]

References

  1. ^ a b c "DODSON, Prof. Eleanor Joy". Who's Who. Vol. 2014 (online Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  2. ^ Professor Guy Dodson, Department of Chemistry, University of York, archived from the original on 2 January 2013, retrieved 29 December 2012.
  3. ^ De Meyts, P. (2013). "In Memoriam: Guy Dodson (1937–2012)". Frontiers in Endocrinology. 4: 33. doi:10.3389/fendo.2013.00033. PMC 3604789.
  4. ^ a b Wigley, D.B.; Davies, G.J.; Dodson, E.J.; Maxwell, A; Dodson, G (1991). "Crystal structure of an N-terminal fragment of the DNA gyrase B protein". Nature. 351 (6328): 624–629. Bibcode:1991Natur.351..624W. doi:10.1038/351624a0. PMID 1646964. S2CID 4373125.
  5. ^ Davies, G. J.; Dodson, G. G.; Hubbard, R. E.; Tolley, S. P.; Dauter, Z.; Wilson, K. S.; Hjort, C.; Mikkelsen, J. M. L.; Rasmussen, G.; Schülein, M. (1993). "Structure and function of endoglucanase V". Nature. 365 (6444): 362–4. Bibcode:1993Natur.365..362D. doi:10.1038/365362a0. PMID 8377830. S2CID 4277867.
  6. ^ Baker, E. N. (2013). "Guy Dodson FRS (1937–2012)". Acta Crystallographica Section D. 69 (3): 490–492. doi:10.1107/S0907444913004186.
  7. ^ Prof Guy Dodson on YouTube
  8. ^ Written evidence submitted by Professor Guy Dodson, FRS, FMS, ForMemINSA, Parliament of the United Kingdom
  9. ^ a b Guy Dodson's publications indexed by the Scopus bibliographic database. (subscription required)
  10. ^ Dodson, George (1961). An X-ray analysis of an alkaloid and some investigation into nickel bis-salicylaldahyde triethylene tetramine (Doctoral thesis). ResearchSpace@Auckland, University of Auckland. hdl:2292/56154.
  11. ^ Blundell, T. L.; Dodson, G. G.; Dodson, E.; Hodgkin, D. C.; Vijayan, M. (1971). "X-ray analysis and the structure of insulin". Recent Progress in Hormone Research. 27: 1–40. doi:10.1016/b978-0-12-571127-2.50025-0. ISBN 9780125711272. PMID 4946130.
  12. ^ Blundell, T.L.; Cutfield, J.F.; Cutfield, S.M.; Dodson, E.J.; Dodson, G.G.; Hodgkin, D.C.; Mercola, D.A.; Vijayan, M. (1971). "Atomic positions in rhombohedral 2-zinc insulin crystals". Nature. 231 (5304): 506–511. Bibcode:1971Natur.231..506B. doi:10.1038/231506a0. PMID 4932997. S2CID 4158731.
  13. ^ Adam, M. G.; Coller, L.; Hodgkin, D. C.; Dodson, G. G. (1966). "X-ray crystallographic studies on zinc insulin crystals". The American Journal of Medicine. 40 (5): 667–671. doi:10.1016/0002-9343(66)90146-X. PMID 5941965.
  14. ^ Dodson, Guy (2002). "Dorothy Mary Crowfoot Hodgkin, O.M. 12 May 1910 – 29 July 1994". Biographical Memoirs of Fellows of the Royal Society. 48: 179–219. doi:10.1098/rsbm.2002.0011. PMID 13678070. S2CID 61764553.
  15. ^ Brzozowski, A. M.; Derewenda, U.; Derewenda, Z. S.; Dodson, G. G.; Lawson, D. M.; Turkenburg, J. P.; Bjorkling, F.; Huge-Jensen, B.; Patkar, S. A.; Thim, L. (1991). "A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex". Nature. 351 (6326): 491–494. Bibcode:1991Natur.351..491B. doi:10.1038/351491a0. PMID 2046751. S2CID 4343187.
  16. ^ Brady, L.; Brzozowski, A. M.; Derewenda, Z. S.; Dodson, E.; Dodson, G.; Tolley, S.; Turkenburg, J. P.; Christiansen, L.; Huge-Jensen, B.; Norskov, L.; Thim, L.; Menge, U. (1990). "A serine protease triad forms the catalytic centre of a triacylglycerol lipase". Nature. 343 (6260): 767–70. Bibcode:1990Natur.343..767B. doi:10.1038/343767a0. PMID 2304552. S2CID 4308111.
  17. ^ Perutz, M. F.; Wilkinson, A. J.; Paoli, M.; Dodson, G. G. (1998). "The Stereochemical Mechanism of the Cooperative Effects in Hemoglobin Revisited". Annual Review of Biophysics and Biomolecular Structure. 27: 1–34. doi:10.1146/annurev.biophys.27.1.1. PMID 9646860.
  18. ^ Dodson, Eleanor (2020). "Guy Dodson. 13 January 1937—24 December 2012". Biographical Memoirs of Fellows of the Royal Society. 68: 151–174. doi:10.1098/rsbm.2019.0042. S2CID 212737449.
  19. ^ "EC/1994/13:Dodson, George Guy". London: The Royal Society. Archived from the original on 4 April 2017. Retrieved 29 October 2014.
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