HACL1
| HACL1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | HACL1, 2-HPCL, HPCL, HPCL2, PHYH2, 2-hydroxyacyl-CoA lyase 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604300; MGI: 1929657; GeneCards: HACL1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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2-hydroxyacyl-CoA lyase 1 is a protein that in humans is encoded by the HACL1 gene. It produces a 2-Hydroxyphytanoyl-CoA lyase.[5]
Function
The product is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[6]
The corresponding EC number is 4.1.2.63.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131373 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021884 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: 2-hydroxyacyl-CoA lyase 1". Retrieved 2016-04-10.
- ^ Foulon V, Antonenkov V, Croes K, et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. Bibcode:1999PNAS...9610039F. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.
Further reading
- Foulon V, Antonenkov VD, Croes K, Waelkens E, Mannaerts GP, Van Veldhoven PP, Casteels M (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. Bibcode:1999PNAS...9610039F. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.
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