HGFAC

HGFAC

Identifiers

HGFAC, HGFA, HGF activator

External IDs

OMIM: 604552; MGI: 1859281; GeneCards: HGFAC

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1YBW, 1YC0, 2R0K, 2R0L, 2WUB, 2WUC, 3K2U

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4p16.3	Start	3,441,968 bp^[1]
Band	4p16.3	End	3,449,486 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 B2	Start	35,198,853 bp^[2]
Band	5\|5 B2	End	35,205,805 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

right testis

left testis

right hemisphere of cerebellum

right uterine tube

ganglionic eminence

testicle

right frontal lobe

ventricular zone

anterior pituitary

Top expressed in

left lobe of liver

crypt of lieberkuhn of small intestine

large intestine

islet of Langerhans

left colon

duodenum

pyloric antrum

fetal liver hematopoietic progenitor cell

right kidney

jejunum

More reference expression data


More reference expression data

Gene ontology
Molecular function	peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity
Cellular component	extracellular region extracellular space cytosol rough endoplasmic reticulum
Biological process	proteolysis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


3083


54426


ENSG00000109758


ENSMUSG00000029102


Q04756


Q9R098

RefSeq (mRNA)


NM_001297439 NM_001528


NM_019447

RefSeq (protein)


NP_001284368 NP_001519


NP_062320

Location (UCSC)

Chr 4: 3.44 – 3.45 Mb

Chr 5: 35.2 – 35.21 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.^[5]^[6]^[7]

The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029102 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII". J Biol Chem. 268 (14): 10024–8. doi:10.1016/S0021-9258(18)82167-6. PMID 7683665.
^ Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin". J Biol Chem. 268 (30): 22927–32. doi:10.1016/S0021-9258(18)41615-8. PMID 8226803.
^ ^a ^b "Entrez Gene: HGFAC HGF activator".

Further reading

Nakamura T (1992). "Structure and function of hepatocyte growth factor". Prog. Growth Factor Res. 3 (1): 67–85. doi:10.1016/0955-2235(91)90014-U. PMID 1838014.
Shimomura T, Ochiai M, Kondo J, Morimoto Y (1992). "A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture". Cytotechnology. 8 (3): 219–29. doi:10.1007/BF02522039. PMID 1368819. S2CID 24061579.
Miyazawa K, Shimomura T, Kitamura N (1996). "Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator". J. Biol. Chem. 271 (7): 3615–8. doi:10.1074/jbc.271.7.3615. PMID 8631970.
Shimomura T, Denda K, Kitamura A, et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (10): 6370–6. doi:10.1074/jbc.272.10.6370. PMID 9045658.
Kawaguchi T, Qin L, Shimomura T, et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890.
Miyazawa K, Wang Y, Minoshima S, et al. (1999). "Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator". Eur. J. Biochem. 258 (2): 355–61. doi:10.1046/j.1432-1327.1998.2580355.x. PMID 9874200.
Kataoka H, Shimomura T, Kawaguchi T, et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.
Kataoka H, Meng JY, Itoh H, et al. (2001). "Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta". Histochem. Cell Biol. 114 (6): 469–75. doi:10.1007/s004180000228. PMID 11201608. S2CID 25947109.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Tjin EP, Derksen PW, Kataoka H, et al. (2004). "Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator". Blood. 104 (7): 2172–5. doi:10.1182/blood-2003-12-4386. PMID 15172968.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Shia S, Stamos J, Kirchhofer D, et al. (2005). "Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B". J. Mol. Biol. 346 (5): 1335–49. doi:10.1016/j.jmb.2004.12.048. PMID 15713485.
Tjin EP, Groen RW, Vogelzang I, et al. (2006). "Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma". Blood. 107 (2): 760–8. doi:10.1182/blood-2005-05-1929. PMID 16189274.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

v t e PDB gallery
1ybw: Protease domain of HGFA with no inhibitor 1yc0: short form HGFA with first Kunitz domain from HAI-1

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