HOTTIP

HOTTIP
Identifiers
AliasesHOXA transcript at the distal tiplong noncoding RNA HOTTIPhuman
External IDsGeneCards: [1]
Orthologs
Databasesn/a
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

In molecular biology, HOTTIP (HOXA transcript at the distal tip) is a long non-coding RNA. The gene encoding HOTTIP is located at the 5′ tip of the HOXA locus, and coordinates the activation of several of the 5′ HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping. HOTTIP binds to the WDR5 protein, which forms a complex with the histone methyltransferase protein MLL. This targets the WDR5-MLL complex to the HOXA region and results in H3K4 methylation and transcriptional activation of the HOXA locus.[1] More recently, HOTTIP has been shown to play a role in hepatocellular carcinoma (HCC) progression. HOTTIP expression levels predict metastasis and poor disease outcome in HCC patients. [2] HOTTIP has been shown to be transcriptionally regulated by a transcriptional coactivator PSIP1/p52[3]

See also

References

  1. ^ Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature. 472 (7341): 120–124. Bibcode:2011Natur.472..120W. doi:10.1038/nature09819. PMC 3670758. PMID 21423168.
  2. ^ Quagliata, L; Matter, MS; Piscuoglio, S; Arabi, L; Ruiz, C; Procino, A; Kovac, M; Moretti, F; Makowska, Z; Boldanova, T; Andersen, JB; Hämmerle, M; Tornillo, L; Heim, MH; Diederichs, S; Cillo, C; Terracciano, LM (2014). "Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients". Hepatology. 59 (3): 911–23. doi:10.1002/hep.26740. PMC 3943759. PMID 24114970.
  3. ^ Pradeepa, Madapura M.; McKenna, Fionnuala; Taylor, Gillian C. A.; Bengani, Hemant; Grimes, Graeme R.; Wood, Andrew J.; Bhatia, Shipra; Bickmore, Wendy A. (2017-04-06). "Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip". PLOS Genetics. 13 (4) e1006677. doi:10.1371/journal.pgen.1006677. ISSN 1553-7404. PMC 5383017. PMID 28384324.

Further reading

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.