Helicobacter felis
Species of bacterium
Helicobacter felis is a bacterial species in the Helicobacteraceae family, Campylobacterales order,[ 1] Helicobacter genus . This bacterium is Gram-negative , microaerophilic , urease -positive, and spiral-shaped. Its type strain is CS1T (= ATCC 49179T). It can be pathogenic .[ 2] [ 3] [ 4]
Helicobacter pylori (H. pylori ) is by far the best known Helicobacter species, primarily because humans infected with it may develop gastrointestinal tract diseases such as stomach inflammation , stomach ulcers , duodenal ulcers , stomach cancers of the nonlymphoma type, and various subtypes of extranodal marginal zone lymphomass , e.g. those of the stomach , small intestines , large intestines , and rectumn . H. pylori is also associated with the development of bile duct cancer and has been associated with a wide range of other diseases although its role in the development of many of these other diseases requires further study.[ 5] Humans infected with H. felis may also develop some of the same gastrointestinal diseases viz., stomach inflammation, stomach ulcers,[ 6] duodenal ulcers,[ 7] stomach cancers that are not lymphomas, and extranodal marginal B cell lymphomas of the stomach.[ 6] Other non-H. pylori species that are known to be associated with these gastrointestinal diseases are Helicobacter bizzozeronii , Helicobacter salomonis , Helicobacter suis , and Helicobacter heilmannii s.s . Because of their disease associations, these four Helicobacter species plus H. felis are often group together and termed Helicobacter heilmannii sensu lato .
H. felis bacteria are detected in the stomachs of their natural hosts - cats, dogs, rabbits, and cheetahs. Reports suggest that individuals, including children,[ 7] are infected with this bacterium by having close contact with one of these infected animals:[ 6] H. heilmanni s.l. -associated diseases, including those associated with H. felis , appear to be zoonotic diseases , i.e. infectious diseases that are caused by pathogen that spread from animals to humans.[ 6] It is important to diagnose H. felis and other H. heilmannii sensu lato infections in patients with the cited upper gastrointestinal tract diseases , including in particular extranodal marginal zone lymphoma of the stomach, because some of them have been successfully treated and cured using antibiotic-based drug regimens (e.g.amoxicillin , clarithromycin , plus a proton pump inhibitor [ 8] or metronidazole , clarithromycin, plus a proton pump inhibitor[ 6] ) directed against the instigating bacterium.[ 6]
References
^ Paster, B. J.; Lee, A.; Fox, J. G.; Dewhirst, F. E.; Tordoff, L. A.; Fraser, G. J.; O'Rourke, J. L.; Taylor, N. S.; Ferrero, R. (1991). "Phylogeny of Helicobacter felis sp. nov., Helicobacter mustelae, and Related Bacteria" . International Journal of Systematic Bacteriology . 41 (1): 31–38. doi :10.1099/00207713-41-1-31 . ISSN 0020-7713 . PMID 1704791 .
^ Simpson, K. W.; Strauss-Ayali, D.; Scanziani, E.; Straubinger, R. K.; McDonough, P. L.; Straubinger, A. F.; Chang, Y.-F.; Domeneghini, C.; Arebi, N.; Calam, J. (2000). "Helicobacter felis Infection Is Associated with Lymphoid Follicular Hyperplasia and Mild Gastritis but Normal Gastric Secretory Function in Cats" . Infection and Immunity . 68 (2): 779–790. doi :10.1128/IAI.68.2.779-790.2000 . ISSN 0019-9567 . PMC 97205 . PMID 10639446 .
^ Fritz, E. L.; Slavik, T.; Delport, W.; Olivier, B.; van der Merwe, S. W. (2006). "Incidence of Helicobacter felis and the Effect of Coinfection with Helicobacter pylori on the Gastric Mucosa in the African Population" . Journal of Clinical Microbiology . 44 (5): 1692–1696. doi :10.1128/JCM.44.5.1692-1696.2006 . ISSN 0095-1137 . PMC 1479211 . PMID 16672395 .
^ Péré-Védrenne C, Flahou B, Loke MF, Ménard A, Vadivelu J (September 2017). "Other Helicobacters, gastric and gut microbiota". Helicobacter . 22 (Suppl 1): e12407. doi :10.1111/hel.12407 . PMID 28891140 . S2CID 30040441 .
^ Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF (July 2018). "Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects" . World Journal of Gastroenterology . 24 (28): 3071–3089. doi :10.3748/wjg.v24.i28.3071 . PMC 6064966 . PMID 30065554 .
^ a b c d e f Bento-Miranda M, Figueiredo C (December 2014). "Helicobacter heilmannii sensu lato: an overview of the infection in humans" . World Journal of Gastroenterology . 20 (47): 17779–87. doi :10.3748/wjg.v20.i47.17779 . PMC 4273128 . PMID 25548476 .
^ a b Iwanczak B, Biernat M, Iwanczak F, Grabinska J, Matusiewicz K, Gosciniak G (April 2012). "The clinical aspects of Helicobacter heilmannii infection in children with dyspeptic symptoms". Journal of Physiology and Pharmacology . 63 (2): 133–6. PMID 22653899 .
^ Ménard A, Smet A (September 2019). "Review: Other Helicobacter species". Helicobacter . 24 (Suppl 1): e12645. doi :10.1111/hel.12645 . PMID 31486233 . S2CID 201838021 .
Further reading
Schmitz JM, Durham CG, Schoeb TR, et al. (September 2011). "Helicobacter felis--associated gastric disease in microbiota-restricted mice" . Journal of Histochemistry and Cytochemistry . 59 (9): 826–41. doi :10.1369/0022155411416242 . PMC 3201166 . PMID 21852692 .
Ferrero RL, Avé P, Radcliff FJ, Labigne A, Huerre MR (July 2000). "Outbred mice with long-term Helicobacter felis infection develop both gastric lymphoid tissue and glandular hyperplastic lesions". The Journal of Pathology . 191 (3): 333–40. doi :10.1002/1096-9896(2000)9999:9999<::AID-PATH619>3.0.CO;2-H . PMID 10878557 . S2CID 23300220 .
Ericksen, Russell E.; Rose, Shannon; Westphalen, Christoph Benedikt; Shibata, Wataru; Muthupalani, Sureshkumar; Tailor, Yagnesh; Friedman, Richard A.; Han, Weiping; Fox, James G.; Ferrante Jr., Anthony W.; Wang, Timothy C (March 2014). "Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response" . Gut . 63 (3): 385–394. doi :10.1136/gutjnl-2013-305092 . PMC 3972255 . PMID 23729675 .
External links