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IFI30
Identifiers
Aliases	IFI30, GILT, IFI-30, IP30, IP-30, lysosomal thiol reductase, IFI30 lysosomal thiol reductase
External IDs	OMIM: 604664; MGI: 2137648; GeneCards: IFI30
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,178,117 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,219,307 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; appendix; ; spleen; ; upper lobe of left lung; ; right lung; ; lymph node; ; duodenum; ; right adrenal cortex;
	Top expressed in
	spleen; ; duodenum; ; colon; ; yolk sac; ; jejunum; ; stomach; ; ileum; ; thymus; ; zone of skin; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; protein binding; oxidoreductase activity, acting on a sulfur group of donors;
Cellular component	extracellular region; cell junction; lysosomal lumen; intracellular membrane-bounded organelle; lysosome; cytosol;
Biological process	interferon-gamma-mediated signaling pathway; immune system process; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of exogenous peptide antigen via MHC class I;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10437
	65972
	ENSG00000216490
	ENSMUSG00000031838
	P13284
	Q9ESY9
	NM_006332
	NM_023065
	NP_006323
	NP_075552
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.^[5]^[6]^[7]

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000216490 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031838 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. doi:10.1016/S0021-9258(18)37889-X. PMID 3136170.
^ Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. Bibcode:2000PNAS...97..745A. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.
^ ^a ^b "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet. 20 (1): 1. PMID 16170.
Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association. 52 (1): 9. PMID 1069150.
Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. doi:10.1074/jbc.M003459200. PMID 10852914.
Phan UT, Maric M, Dick TP, Cresswell P (2001). "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics. 53 (4): 342–6. doi:10.1007/s002510100323. PMID 11491538. S2CID 848449.
Haque MA, Li P, Jackson SK, et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMC 2193747. PMID 12021307.
Phan UT, Lackman RL, Cresswell P (2002). "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. Bibcode:2002PNAS...9912298P. doi:10.1073/pnas.182430499. PMC 129439. PMID 12198183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000216490 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031838 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3136170-5] Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. doi:10.1016/S0021-9258(18)37889-X. PMID 3136170.

[pmid10639150-6] Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. Bibcode:2000PNAS...97..745A. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.

[entrez-7] "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

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IFI30

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