INTS3

INTS3

Identifiers

INTS3, C1orf193, C1orf60, INT3, SOSS-A, SOSSA, integrator complex subunit 3

External IDs

OMIM: 611347; MGI: 2140050; GeneCards: INTS3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4OWT, 4OWW, 4OWX

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	153,728,050 bp^[1]
Band	1q21.3	End	153,774,808 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F1	Start	90,298,695 bp^[2]
Band	3\|3 F1	End	90,340,929 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right uterine tube

pituitary gland

right ovary

left ovary

anterior pituitary

canal of the cervix

body of uterus

right adrenal gland

right adrenal cortex

ascending aorta

Top expressed in

tail of embryo

Paneth cell

Ileal epithelium

genital tubercle

secondary oocyte

yolk sac

zygote

habenula

epiblast

primitive streak

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	integrator complex SOSS complex nucleus nucleoplasm nucleolus cytoplasm
Biological process	response to ionizing radiation DNA repair snRNA processing cellular response to DNA damage stimulus mitotic cell cycle checkpoint signaling snRNA transcription by RNA polymerase II
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


65123


229543


ENSG00000143624 ENSG00000262826


ENSMUSG00000027933


Q68E01


Q7TPD0

RefSeq (mRNA)


NM_023015 NM_001324475


NM_145540 NM_178876

RefSeq (protein)


NP_001311404 NP_075391


NP_663515 NP_849207

Location (UCSC)

Chr 1: 153.73 – 153.77 Mb

Chr 3: 90.3 – 90.34 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Integrator complex subunit 3 is a protein that in humans is encoded by the INTS3 gene.^[5]^[6]

References

^ ^a ^b ^c ENSG00000262826 GRCh38: Ensembl release 89: ENSG00000143624, ENSG00000262826 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027933 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144. S2CID 18069461.
^ "Entrez Gene: INTS3 integrator complex subunit 3".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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