Santone was born on October 1, 1893, in Campobasso, Italy. His high school is unknown. Santone did not attend college. In 1926, he made two appearances for the Hartford Blues of the National Football League (NFL) as a guard.[1] His weight was listed at 180, but his height is unknown.[2] He did not make any more appearances after the season as the Blues folded from the league.[3] He later lived in Hartford, Connecticut, and died there on October 27, 1963, at the age of 70.[4]