Spagnola was born in Bethlehem, Pennsylvania. As a Boy Scout at Notre Dame Elementary School, he was awarded the Eagle Scout rank, and was inducted into the Eagle Scout Hall of Fame.
After his 1975 graduation from Bethlehem Catholic, he attended Yale University, where he played wide receiver. He graduated in 1979 as the university's all-time leading wide receiver in receptions (88) and yards (1554). He was an honorable mention All-American tight end at Yale in 1979.
Spagnola was voted the Eagles' MVP (offensive) in 1984. His best year in the NFL came during the 1985 season for the Philadelphia Eagles when he caught 65 receptions for 701 yards and five touchdowns. In 1985, Spagnola and Mike Quick combined to set two club records; most receptions by two players (135) and most combined receiving yards (2,019), breaking a record previously shared by Hall of Famer Tommy McDonald and Timmy Brown.
He was a pro-bowl alternative in 1985 and 1984. He caught more passes (129) than any other tight end in the National Football Conference in 1985 and 1984.
Spagnola ranks 14th on the Eagles' all-time reception list with 256 catches for 2,833 yards. His 12 catches in one game against the New Orleans Saints in 1985 were just two short of the club record shared by Brian Westbrook and Don Looney.
In 2008-2009, Spagnola was sought by the National Football League Players Association's executive search firm Reilly Partners in Chicago to succeed Gene Upshaw as executive director. Spagnola remained in the running after the union pared its list of finalists to five.
In 1984, Spagnola began his career in the financial services industry, working for First Boston Corporation in New York City and Philadelphia. During this time, Spagnola worked in institutional sales and trading where he developed an in depth knowledge of capital markets, proprietary trading. and corporate underwriting.
In 1992, with Michael Cosack, he co-founded Spagnola-Cosack, Inc., an independent investment consulting firm that serviced public, Taft-Hartley, corporate, hospital, endowment, and foundation Funds. Over a ten-year period, assets under advisement grew to over $3.5 billion. In 2003, Spagnola-Cosack, Inc. was acquired by Public Financial Management Group, a Philadelphia financial advisory firm. He brings over 23 years of investment experience to PFM Advisors.
As managing director of PFM Advisors, Spagnola serves on the investment committee, oversees marketing and client service and consulting with public, hospital, endowment, and Taft-Hartley Fund clients of the firm.