KIAA1967
Protein-coding gene in the species Homo sapiens
KIAA1967 , also known as Deleted in Breast Cancer 1 , is a protein which in humans is encoded by the KIAA1967 gene .[ 5] [ 6] [ 7]
Function
Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1 , which deacetylates histones and p53 .[ 8] [ 9] [ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000158941 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033712 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: KIAA1967 KIAA1967" .^ Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res . 8 (6): 319– 27. doi :10.1093/dnares/8.6.319 . PMID 11853319 . ^ Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH (October 2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer" . Proc. Natl. Acad. Sci. U.S.A . 99 (21): 13647– 52. Bibcode :2002PNAS...9913647H . doi :10.1073/pnas.212516099 PMC 129730 PMID 12370419 . ^ Kim JE, Chen J, Lou Z (January 2008). "DBC1 is a negative regulator of SIRT1". Nature . 451 (7178): 583– 6. Bibcode :2008Natur.451..583K . doi :10.1038/nature06500 . PMID 18235501 . S2CID 4420753 . ^ Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (January 2008). "Negative regulation of the deacetylase SIRT1 by DBC1" . Nature . 451 (7178): 587– 90. Bibcode :2008Natur.451..587Z . doi :10.1038/nature06515 . PMC 2866287 PMID 18235502 . ^ Anantharaman V, Aravind L (May 2008). "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites" . Cell Cycle . 7 (10): 1467– 72. doi :10.4161/cc.7.10.5883 . PMC 2423810 PMID 18418069 .
Further reading
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788– 95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422– 35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res . 8 (6): 319– 27. doi :10.1093/dnares/8.6.319 . PMID 11853319 . Hamaguchi M, Meth JL, von Klitzing C, et al. (2002). "DBC2, a candidate for a tumor suppressor gene involved in breast cancer" . Proc. Natl. Acad. Sci. U.S.A . 99 (21): 13647– 52. Bibcode :2002PNAS...9913647H . doi :10.1073/pnas.212516099 PMC 129730 PMID 12370419 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97– 105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130– 5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093– 101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136– 44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Sundararajan R, Chen G, Mukherjee C, White E (2005). "Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling". Oncogene . 24 (31): 4908– 20. doi :10.1038/sj.onc.1208681 . PMID 15824730 . S2CID 28591041 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach" . Cell Cycle . 6 (2): 205– 17. doi :10.4161/cc.6.2.3742 PMID 17314511 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Trauernicht AM, Kim SJ, Kim NH, Boyer TG (2007). "Modulation of estrogen receptor alpha protein level and survival function by DBC-1" . Mol. Endocrinol . 21 (7): 1526– 36. doi :10.1210/me.2007-0064 PMID 17473282 .
