KRT41P

KRT41P
Identifiers
AliasesKRT41P, hHaA, phihHaA, KRTHAP1, keratin 41 pseudogene, keratin 41, pseudogene
External IDsGeneCards: KRT41P
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

8686

n/a

Ensembl

ENSG00000225438

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 17: 41.41 – 41.41 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

KRT41P,[3] formerly KRTHAP1 (also known as ΨhHaA, h prefix for "human") is a human pseudogene that used to code for a keratin. It is believed to be responsible for fur-like body hair.[4]

There is still variation in the degree of body hair among human beings and occasional examples have been found of people where the gene is active leading to very thick body hair as a result. Although the mutation was dated to 240 000 by Winter et al., it is also present in the Vindija Neandertal and Altai Denisovan sequences. Hence the dating must be older than 700 00 kya and possibly more than 1 mya considering the latter's divergence date. Given the divergence of pubic and head hair lice, the date of the mutation may be as old as 3.3 million years old.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000225438 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "KRT41P Gene - Keratin 41, Pseudogene". Genecards.org.
  4. ^ a b Winter H, Langbein L, Krawczak M, Cooper DN, Jave-Suarez LF, Rogers MA, et al. (January 2001). "Human type I hair keratin pseudogene phihHaA has functional orthologs in the chimpanzee and gorilla: evidence for recent inactivation of the human gene after the Pan-Homo divergence". Human Genetics. 108 (1): 37–42. doi:10.1007/s004390000439. PMID 11214905. S2CID 21545865.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.