LIN7A

LIN7A

Identifiers

LIN7A, LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1

External IDs

OMIM: 603380; MGI: 2135609; GeneCards: LIN7A

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q21.31	Start	80,792,520 bp^[1]
Band	12q21.31	End	80,937,934 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D1	Start	107,107,547 bp^[2]
Band	10\|10 D1	End	107,257,335 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

endothelial cell

middle temporal gyrus

retinal pigment epithelium

primary visual cortex

trabecular bone

blood

cerebellar cortex

cerebellar hemisphere

entorhinal cortex

Top expressed in

lobe of cerebellum

seminiferous tubule

cerebellar vermis

lateral septal nucleus

lumbar spinal ganglion

nucleus accumbens

neural layer of retina

primary motor cortex

inferior colliculi

superior cervical ganglion

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding L27 domain binding
Cellular component	postsynaptic membrane membrane postsynaptic density cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection extracellular exosome presynapse synapse MPP7-DLG1-LIN7 complex intracellular anatomical structure
Biological process	protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport synaptic vesicle transport inner ear development neurotransmitter secretion exocytosis transport protein-containing complex assembly
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8825


108030


ENSG00000111052


ENSMUSG00000019906


O14910


Q8JZS0

RefSeq (mRNA)


NM_004664 NM_001324423


NM_001033223 NM_001039354 NM_001284329

RefSeq (protein)


NP_001311352 NP_004655


NP_001028395 NP_001034443 NP_001271258

Location (UCSC)

Chr 12: 80.79 – 80.94 Mb

Chr 10: 107.11 – 107.26 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.^[5]^[6]^[7]

Interactions

LIN7A has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111052 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019906 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
^ Bohl J, Brimer N, Lyons C, Vande Pol SB (Mar 2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J Biol Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
^ "Entrez Gene: LIN7A lin-7 homolog A (C. elegans)".
^ ^a ^b ^c Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
^ Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (Nov 1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi:10.1074/jbc.273.48.31633. PMID 9822620.
^ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

Further reading

Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. S2CID 12465062.
Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi:10.1074/jbc.273.48.31633. PMID 9822620.
Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B (1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain". J. Neurosci. 19 (4): 1307–16. doi:10.1523/JNEUROSCI.19-04-01307.1999. PMC 6786035. PMID 9952408.
Perego C, Vanoni C, Villa A, Longhi R, Kaech SM, Fröhli E, Hajnal A, Kim SK, Pietrini G (1999). "PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells". EMBO J. 18 (9): 2384–93. doi:10.1093/emboj/18.9.2384. PMC 1171321. PMID 10228153.
Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
Harris BZ, Venkatasubrahmanyam S, Lim WA (2002). "Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes". J. Biol. Chem. 277 (38): 34902–8. doi:10.1074/jbc.M205856200. PMID 12110687.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Olsen O, Wade JB, Morin N, Bredt DS, Welling PA (2005). "Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney". Am. J. Physiol. Renal Physiol. 288 (2): F345–52. doi:10.1152/ajprenal.00235.2004. PMID 15494546. S2CID 36221552.
Dode L, Andersen JP, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F (2006). "Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses". J. Biol. Chem. 280 (47): 39124–34. doi:10.1074/jbc.M506181200. PMID 16192278.

v t e PDB gallery
2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.