LIN7B

LIN7B

Identifiers

LIN7B, LIN-7B, MALS-2, MALS2, VELI2, lin-7 homolog B, crumbs cell polarity complex component

External IDs

OMIM: 612331; MGI: 1330858; GeneCards: LIN7B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DKR

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	49,114,324 bp^[1]
Band	19q13.33	End	49,118,460 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	45,017,315 bp^[2]
Band	7\|7 B3	End	45,020,007 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

anterior cingulate cortex

endothelial cell

right frontal lobe

nucleus accumbens

Brodmann area 9

anterior pituitary

prefrontal cortex

amygdala

caudate nucleus

putamen

Top expressed in

facial motor nucleus

motor neuron

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

primary visual cortex

substantia nigra

barrel cortex

primary motor cortex

anterior amygdaloid area

Region I of hippocampus proper

More reference expression data


More reference expression data

Gene ontology
Molecular function	PDZ domain binding protein domain specific binding L27 domain binding protein binding
Cellular component	postsynaptic membrane postsynaptic density membrane cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection presynapse synapse MPP7-DLG1-LIN7 complex
Biological process	protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport neurotransmitter secretion exocytosis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


64130


22342


ENSG00000104863


ENSMUSG00000003872


Q9HAP6


O88951

RefSeq (mRNA)


NM_001308419 NM_022165


NM_011698

RefSeq (protein)


NP_001295348 NP_071448


NP_035828

Location (UCSC)

Chr 19: 49.11 – 49.12 Mb

Chr 7: 45.02 – 45.02 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.^[5]^[6]

Interactions

LIN7B has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104863 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. doi:10.1523/JNEUROSCI.19-11-04189.1999. PMC 6782594. PMID 10341223.
^ "Entrez Gene: LIN7B lin-7 homolog B (C. elegans)".
^ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
^ Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
^ Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
^ Olsen O, Liu H, Wade JB, Merot J, Welling PA (Jan 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183-95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Further reading

Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. S2CID 12465062.
Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.
Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, Mège RM, Mulle C (2002). "Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes". J. Neurosci. 22 (15): 6426–36. doi:10.1523/JNEUROSCI.22-15-06426.2002. PMC 6758172. PMID 12151522.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. Bibcode:2003FEBSL.554...30H. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. doi:10.1074/jbc.M510187200. PMID 16192269.
Kawai S, Fukuda C, Mukai T, Murata K (2006). "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase". J. Biol. Chem. 280 (47): 39200–7. doi:10.1074/jbc.M506426200. PMID 16192277.
Li Z, Benard O, Margolskee RF (2006). "Ggamma13 interacts with PDZ domain-containing proteins". J. Biol. Chem. 281 (16): 11066–73. doi:10.1074/jbc.M600113200. PMID 16473877.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (2007). "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons". Neurosci. Res. 56 (4): 347–55. doi:10.1016/j.neures.2006.08.003. PMID 16979770. S2CID 45834664.

v t e PDB gallery
1y74: Solution Structure of mLin-2/mLin-7 L27 Domain Complex 2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B

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