ARTIKELDIGITAL.COM

LOXL4
Identifiers
Aliases	LOXL4, LOXC, lysyl oxidase like 4
External IDs	OMIM: 607318; MGI: 1914823; GeneCards: LOXL4
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	98,268,194 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	42,601,252 bp
RNA expression pattern
	Top expressed in
	tibia; ; islet of Langerhans; ; cartilage tissue; ; tibialis anterior muscle; ; pancreatic epithelial cell; ; tendon of biceps brachii; ; pancreatic ductal cell; ; olfactory zone of nasal mucosa; ; nasal epithelium; ; stromal cell of endometrium;
	Top expressed in
	membranous bone; ; calvaria; ; Dermatocranium; ; maxilla; ; mandible; ; molar; ; rib; ; lumbar spinal ganglion; ; ascending aorta; ; skin of external ear;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity; oxidoreductase activity; copper ion binding; protein binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; metal ion binding; protein-lysine 6-oxidase activity;
Cellular component	extracellular region; receptor complex; extracellular exosome; membrane; extracellular space;
Biological process	receptor-mediated endocytosis; peptidyl-lysine oxidation; collagen fibril organization; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84171
	67573
	ENSG00000138131
	ENSMUSG00000025185
	Q96JB6
	Q924C6
	NM_032211
	NM_001164311; NM_053083
	NP_115587
	NP_001157783; NP_444313
	Wikidata
View/Edit Human	View/Edit Mouse

Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene.^[5]^[6]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138131 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025185 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T (Jun 2001). "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage". J Biol Chem. 276 (26): 24023–9. doi:10.1074/jbc.M100861200. PMID 11292829.
^ ^a ^b "Entrez Gene: LOXL4 lysyl oxidase-like 4".

Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins". Biochim. Biophys. Acta. 1647 (1–2): 220–4. doi:10.1016/s1570-9639(03)00053-0. PMID 12686136.
Asuncion L, Fogelgren B, Fong KS, et al. (2002). "A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain". Matrix Biol. 20 (7): 487–91. doi:10.1016/S0945-053X(01)00161-5. PMID 11691588.
Mäki JM, Tikkanen H, Kivirikko KI (2002). "Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains". Matrix Biol. 20 (7): 493–6. doi:10.1016/S0945-053X(01)00157-3. PMID 11691589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Holtmeier C, Görögh T, Beier U, et al. (2003). "Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas". Anticancer Res. 23 (3B): 2585–91. PMID 12894545.
Kim MS, Kim SS, Jung ST, et al. (2004). "Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4". J. Biol. Chem. 278 (52): 52071–4. doi:10.1074/jbc.M308856200. PMID 14551188.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Shieh TM, Lin SC, Liu CJ, et al. (2007). "Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis". Clin. Cancer Res. 13 (15 Pt 1): 4378–85. doi:10.1158/1078-0432.CCR-06-2685. PMID 17671119.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138131 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025185 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11292829-5] Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, Nakamura T (Jun 2001). "Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage". J Biol Chem. 276 (26): 24023–9. doi:10.1074/jbc.M100861200. PMID 11292829.

[entrez-6] "Entrez Gene: LOXL4 lysyl oxidase-like 4".

[1]

[2]

[3]

[4]

[5]

[6]

ARTIKELDIGITAL.COM

LOXL4

See also

References

Further reading

Content Disclaimer