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demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene. LSD1 is a flavin-dependent...

is known to inhibit LSD1, an enzyme that selectively demethylates two lysines found on histone H3. Genes promoted downstream of LSD1 are involved in cancer...

of LSD1 activity has emerged as a promising strategy in oncology, UM171—which promotes the ubiquitin-dependent proteasomal degradation of the LSD1–CoREST...

Oxford. Shi is best known for his discovery of lysine-specific demethylase 1 (LSD1/KDM1A) in 2004, which demonstrated that histone methylation is reversible...

was developed to inhibit the human enzyme lysine-specific demethylase-1 (LSD1 or KDM1A EC:1.14.99.66), an oxidating enzyme that mediates demethylation...

ORY-2001) is a dual inhibitor of the enzymes lysine-specific demethylase 1 (LSD1; KDM1A) and monoamine oxidase B (MAO-B) which is under development for the...

cancer. It is a small-molecule inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A). "Seclidemstat - Salarius Pharmaceuticals". AdisInsight. Springer...

RCOR3), LSD1/KDM1A, and HDAC1 or HDAC2. The REST/CoREST/LSD1/HDAC complex couples transcriptional repression (REST) to histone demethylation (LSD1) and deacetylation...

approximately equal to the histone half-life. Histone lysine demethylase LSD1 (later classified as KDM1A) was first identified in 2004 as a nuclear amine...

proteins that plays a scaffolding role in stabilizing the REST / CoREST / LSD1 / HDAC complex. This complex's function is to down regulate gene expression...

methylcytosine dioxygenase 1 (TET1), Lysine (K)-specific demethylase 1A (LSD1) and Calcium and integrin binding protein 1 (CIB1). The use of zinc finger-fusion...

Frampton GM, Foster CT, et al. (February 2012). "Enhancer decommissioning by LSD1 during embryonic stem cell differentiation". Nature. 482 (7384): 221–225...

Miranda-Gonçalves V, Guimarães R, Cantante M, et al. (February 2022). "Ki67 and LSD1 Expression in Testicular Germ Cell Tumors Is Not Associated with Patient...

of the BHC80/PHF21A protein, which is a component of the LSD1 complex. In this complex, LSD1 specifically demethylates H3K4me2 to H3K4me0, and BHC80 binds...

(February 2019). "Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition". Science Signaling. 12 (567) eaau2922. doi:10.1126/scisignal...

revumenib, DOT1L inhibitors such as pinometostat, and agents targeting BRD4, LSD1, and WDR5. Mutations in KMT2A cause Wiedemann-Steiner syndrome. Germline...

ERα by a novel protein CAC1 through association with histone demethylase LSD1". FEBS Lett. 587 (1): 17–22. doi:10.1016/j.febslet.2012.10.054. PMID 23178685...

Kaneko; Maki Kobayashi-Osak; Masayuki Yamamoto; Makoto Kobayashia (2015). "LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation...

Baikonur cosmodrome came the first flight of the rocket product 8К64 No. LSD1-ST. In September 1960, was approved by the state Commission for the flight...

versions of LSD1 share the same target, their expression patterns are vastly different and neuroLSD1 is a truncated version of LSD1. NeuroLSD1 increases...

factor). Here, it serves as a scaffold and recruits the coactivators p300 and LSD1, in addition to several corepressors which include G9a and the Histone deacetylase...

2009.03.051. PMC 2712024. PMID 19527659. Baron R, Vellore NA (Jul 2012). "LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular...

psychedelic hallucinogen Vafidemstat (ORY-2001) – lysine-specific demethylase 1 (LSD1; KDM1A) and monoamine oxidase B (MAO-B) inhibitor Brexpiprazole (Rexulti)...

J, Li H, Kang L, Zhang Y, et al. (May 2011). "RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming...

region and is dependent on Gfi1’s interaction with the histone demethylase LSD1. Gfi1 represses PU.1 transcription factor, and this repression precedes and...

Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6):...

antimitotic drug treatment in vitro, to understand the immunogenic effects of LSD1 inhibition on tumor growth and T cell dynamics, and for the interaction between...

the histone demethylase LSD1. GFI1 activates Hemgn expression through promoter binding, and this activation is enhanced by LSD1-mediated epigenetic modifications...

recruits OCT1 and HCF1, which in turn recruit histone demethylases JMJD2s and LSD1, etc). DNA methylation can occur on viral genomes through recruitment of...

treatment of cells with an estrogen, LSD1 produced H2O2 as a by-product of its enzymatic activity. The oxidation of DNA by LSD1 in the course of the demethylation...

binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex". Molecular Cell. 34 (2): 145–54. doi:10.1016/j.molcel...

Miranda-Gonçalves V, Guimarães R, Cantante M, et al. (2022). "Ki67 and LSD1 Expression in Testicular Germ Cell Tumors Is Not Associated with Patient...

transcriptional silencing. The 3′ end of HOTAIR interacts with the histone demethylase LSD1. It is an important factor in the epigenetic differentiation of skin over...

Modzelewski, A. J.; Cohen, P. E.; Reinberg, D. (2013). "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors"...

AA, Chang S, Khan D, Hosford J, et al. (2019-09-16). "Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase"...

methylation of the Sod2 and MMP-9 genes, an increase in transcription of LSD1, a H3K4 and H3K9 demethylase, and various DNA Methyl-Transferases (DNMTs)...

Sascha; Lingner, Joachim (2014-02-27). "TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres". Cell Reports. 6 (4):...

protein called lysine specific demethylase (LSD1). Preliminary research has aimed to halt the function of LSD1 to prevent the spread of Ewing Sarcoma cells...

(GSK-3β) inhibitor Vafidemstat (ORY-2001) – dual lysine specific demethylase 1 (LSD1) inhibitor and monoamine oxidase B (MAO-B) inhibitor Xenon (NBTX-001) – ionotropic...

modulator [1] [2] Vafidemstat (ORY-2001) – lysine-specific demethylase 1 (LSD1; KDM1A) and monoamine oxidase B (MAO-B) inhibitor KNX-101 – 15-lipoxygenase...

Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6):...

rhabdomyosarcoma. Similarly, expression of another epigenetic modifier, the LSD1 histone demethylase, is increased in chondrosarcoma, Ewing's sarcoma, osteosarcoma...

include deficiencies in PALB2, FANCD2, RAD51, ATM, MRE11, p53, XRCC1 and LSD1. ARID1A, a chromatin modifier, is required for non-homologous end joining...

rather than controls. H3K4me1 is put down by KMT2C (MLL3) and KMT2D (MLL4) LSD1, and the related LSD2/KDM1B demethylate H3K4me1 and H3K4me2. Marks associated...

other epigenetic modifiers such as histone lysine-specific demethylase 1 (LSD1), which is frequently associated with the NuRD complex and subsequently gene...

PMC 419733. PMID 15169860. Maiques-Diaz A, Somervaille TC (August 2016). "LSD1: biologic roles and therapeutic targeting". Epigenomics. 8 (8): 1103–16....

of predicted miR-137 targets via miRecords database. Among these targets, LSD1 (Lysine-specific histone demethylase 1A, also known as KDM1A) has been shown...

Copper(I)/TEMPO-Catalyzed Aerobic Alcohol Oxidation for the Synthesis of LSD1 Inhibitor GSK2879552". Organometallics. 38 (1): 176–184. doi:10.1021/acs...

5 (also called MLDP, LSDP5, or OXPAT). Insects express related proteins, LSD1 and LSD2, in fat bodies. The yeast Saccharomyces cerevisiae expresses PLN1...

methyl groups, while the histone demethylase lysine specific demethylase 1 (LSD1) can remove the activating mark H3K4me. The CtBPs bind to many different...

histones (H3K4me2 and H3K9me2), H3K4 demethylase lysine-specific demethylase 1 (LSD1), and an H3K9me2 methyltransferase SET domain bifurcated 1 (SETDB1) were...

Cellular component histone deacetylase complex transcription regulator complex Lsd1/2 complex nucleus nucleoplasm protein-containing complex Biological process...

Jenuwein T, et al. (March 2007). "Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression". Nature Cell Biology...

of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1". Cancer Research. 76 (21): 6299–6310. doi:10.1158/0008-5472.CAN-16-0356...

protein p300, and HDAC1. There were also decreased levels of HDAC2, HDAC7, and LSD1 expression shown in the peripheral blood mononuclear cells. A notable protein...

instance, the monomethylation of HSP90 lysine 616 by Smyd2, and its reversal by LSD1, regulate enzymatic activity of HSP90. Nitika; Porter, Corey M.; Truman,...