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coupling between an amine and a carboxylic acid within the same molecule. Lactamization is most efficient in this way if the product is a γ-lactam. For example...

for solid-phase peptide synthesis (SPPS), was proven to undergo rapid lactamization, instead of reacting with the N-terminal end of the peptide. Compared...

orthogonal protection removed before undergoing a carbodiimide mediated lactamization, leading to an intermediate. This intermediate, when attached to N-acetylnorleucine...

Nielsen DS, Palmer D, Meldal M, Diness F (December 2020). "C-Terminal lactamization of peptides". Chemical Communications. 57 (7): 895–898. doi:10.1039/d0cc06018f...

Ornithine lactamization...

this represents the formation of the heterocyclic system by simple lactamization. Hydrazobenzene Diethyl n-butylmalonate Oxyphenbutazone, the major metabolite...

Nielsen DS, Palmer D, Meldal M, Diness F (December 2020). "C-Terminal lactamization of peptides". Chemical Communications. 57 (7): 895–898. doi:10.1039/d0cc06018f...

4-α-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole (4). Base-catalyzed lactamization gives (5). The Goldberg reaction completes the synthesis of zomebazam...

2-[(2-methoxy-2-oxoethyl)-methylcarbamoyl]benzoate, PC11644670 (4). Intramolecular lactamization with sodium methoxide afforded Methyl 4-hydroxy-2-methyl-1-oxoisoqu...

crown gall tumors. Belongs to the mannityl family. It is formed by lactamization of agropine. Alanopine Beta-alanopine (2,2'-iminodipropionic acid or...

product might be expected to be initially formed (5'). An intramolecular lactamization to the heterocyclic ring then occurs giving altanserin (6). Serotonin...

benzopiperazinones, and benzodiazepinones, are efficiently prepared. Lactamization reactions are commonly employed to form the heterocycles, usually under...