The district, located in Corpus Christi, Texas, has four campuses; London Elementary, which serves students in grades pre-kindergarten through second grade; London Intermediate, which serves students grades third through fifth grade; London Middle, which serves grades sixth through eighth grade, and London High school, which serves ninth through twelfth grade. The district's high school opened in 2011, and is a 3A school as of the 2020-2021 enrollment year, and serves 1,290 students in grades Pre-K through 12th. LISD contains 98 square miles; with the addition of a new Elementary building, and new Gymnasium wing completed in mid 2020. School mascot is a Pirate.
Some areas are within Aransas Pass ISD; its high school is not in Nueces County Driscoll ISD does not operate any high schools La Gloria Independent School District was initially of Nueces County when it was established in 1909, but moved to Jim Wells County with its new name as of 1911.