LysC

For the protease, see Endoproteinase Lys-C. For the Drosophila protein, see Lysozyme.

LysC is a prokaryotic aspartokinase involved in the biosynthesis of the amino acid lysine. It is found in a variety of bacteria, including Bacillus subtilis, Escherichia coli and Corynebacterium glutamicum.[1] It is notable for containing a riboswitch, a structure in its messenger RNA that prevents its translation when bound to lysine.[2] Such lysine riboswitch thus acts as a mechanism of negative feedback.[1]

References

  1. ^ a b Grundy, F. J.; Lehman, S. C.; Henkin, T. M. (1 October 2003). "The L box regulon: Lysine sensing by leader RNAs of bacterial lysine biosynthesis genes". Proceedings of the National Academy of Sciences. 100 (21): 12057–12062. Bibcode:2003PNAS..10012057G. doi:10.1073/pnas.2133705100. PMC 218712. PMID 14523230.
  2. ^ Sudarsan, N. (16 October 2003). "An mRNA structure in bacteria that controls gene expression by binding lysine". Genes & Development. 17 (21): 2688–2697. doi:10.1101/gad.1140003. PMC 280618. PMID 14597663.

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