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MED7
Identifiers
Aliases	MED7, ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs	OMIM: 605045; MGI: 1913463; GeneCards: MED7
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,159,019 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,333,548 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; sperm; ; germinal epithelium; ; endothelial cell; ; Achilles tendon; ; palpebral conjunctiva; ; kidney tubule; ; corpus epididymis; ; testicle; ; gonad;
	Top expressed in
	medullary collecting duct; ; secondary oocyte; ; renal corpuscle; ; lens; ; primary oocyte; ; atrioventricular valve; ; seminiferous tubule; ; tail of embryo; ; medial ganglionic eminence; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; transcription coregulator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	mediator complex; nucleus; transcription regulator complex; nucleoplasm; ubiquitin ligase complex; nuclear body;
Biological process	regulation of transcription by RNA polymerase II; stem cell population maintenance; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; protein ubiquitination; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9443
	66213
	ENSG00000155868
	ENSMUSG00000020397
	O43513
	Q9CZB6
	NM_004270; NM_001100816
	NM_001104530; NM_001104556; NM_001104557; NM_025426
	NP_001094286; NP_004261
	NP_001098000; NP_001098026; NP_001098027; NP_079702
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.^[5]^[6]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155868 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl:11858/00-001M-0000-0019-A36A-8. PMID 9989412. S2CID 4405569.
^ ^a ^b "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137–42. Bibcode:1999PNAS...96.7137R. doi:10.1073/pnas.96.13.7137. PMC 22029. PMID 10377381.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID 10235267. S2CID 23646963.
Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8538–43. Bibcode:1998PNAS...95.8538J. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain". Genes Dev. 12 (1): 45–54. doi:10.1101/gad.12.1.45. PMC 316402. PMID 9420330.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155868 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020397 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9989412-5] Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. Bibcode:1999Natur.397..446R. doi:10.1038/17141. hdl:11858/00-001M-0000-0019-A36A-8. PMID 9989412. S2CID 4405569.

[entrez-6] "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".

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MED7

References

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