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Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein-coupled receptor (GPCR) that...

IC50 of 450 nM, but is highly selective over the closely related subtype mGluR2 with no effect even at 30,000 nM, and so has been used to study the effects...

orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3). It is used in scientific research in several different areas, showing...

and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3). It is derived from the older mGluR group II agonist eglumegad, and led...

allosterically; e.g. glutamate-dependent signaling via mGluR2 may modulate 5HT2A-ergic activity. Equilibrium between mGluR2/5HT2A is altered against tendency towards...

selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3). It has been useful in the mapping of the group II mGluR receptor proteins...

metabotropic glutamate receptors (mGluR2/3), with slight selectivity for mGluR2 although not sufficient to distinguish mGluR2 and mGluR3 responses from each...

group II subtype mGluR2. It has potentially antipsychotic effects in animal models, and is used for researching the role of mGluR2 receptors in schizophrenia...

group-selective agonist for the group II metabotropic glutamate receptors (mGluR2/3). It is unclear whether eglumetad directly interacts with dopamine D2...

is an epimer of another metabotropic glutamate receptor antagonist, the mGluR2/3-selective LY-341,495. Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH,...

modulator – schizophrenia [135] ADX-71149 (JNJ-1813; JNJ-40411813; JNJ-mGluR2-PAM) – metabotropic glutamate mGlu2 receptor positive allosteric modulator...

selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic...

metabotropic glutamate mGlu5 receptor modulators [102] Research programme: mGluR2 modulators - Addex Pharmaceuticals/Ortho-McNeil (ADX-92639; JNJ-40068782)...

selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), with reasonable selectivity for mGluR3. While it is some five times...

selective antagonist for group II of the metabotropic glutamate receptors (mGluR2/3). It produces antidepressant and anxiolytic effects in animal studies...

II metabotropic glutamate receptors, mGluR2 and mGluR3. RO4491533 acts as a negative allosteric modulator of mGluR2 and mGluR3. Different types of mGluRs...

Fenobam Mavoglurant Célanire S, Duvey G, Poli S, Rocher JP (January 2012). "mGluR2 activators and mGluR5 blockers advancing in the clinic for major CNS disorders...

CXCR4 receptor Dopamine D2, D3 and D4 receptors GABAB receptor Glutamate mGluR2, mGluR3, mGluR4, mGluR6, mGluR7, & mGluR8 receptors Histamine H3 & H4 receptors...

isoform mGluR2 are known since 2013. with a bicyclo[3.1.0]hexane skeleton MGS-0028 LY404040 LY379268 LY354740; its (+)-C4α-methyl analog is a GluR2 agonist...

selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and was useful in early studies of this receptor family, although it...

reuptake inhibitor (SNRI) [4] ADX-71149 (JNJ-1813; JNJ-40411813; JNJ-mGluR2-PAM) – metabotropic glutamate mGlu2 receptor positive allosteric modulator...

5-HT2A and 5-HT2C receptor antagonist ADX-71149 (JNJ-1813; JNJ-40411813; JNJ-mGluR2-PAM) – metabotropic glutamate mGlu2 receptor modulator Amesergide (LY-237733)...

positive allosteric modulator (PAM) of the metabotropic glutamate receptor 2 (mGluR2), being developed as a potential treatment for nicotine dependence and other...

psychiatric disorders [65] ADX-71149 (ADX71149; JNJ-1813; JNJ-40411813; JNJ-mGluR2-PAM) – metabotropic glutamate mGlu2 receptor positive allosteric modulator...

using 5HT2A receptor agonists that do not have constitutive activity at the mGluR2 dimer, such as lisuride. Tianeptine, an atypical antidepressant, is thought...

allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2. In animal studies it showed anxiolytic and antipsychotic effects, and blocked...

II subtype mGluR2. It is used to study the structure and function of this receptor subtype, and LY-487,379 along with various other mGluR2/3 agonists...

glutamate release into the extracellular space. This glutamate in turn acts on mGluR2/3 receptors, and at higher doses of acetylcysteine, mGluR5. Acetylcysteine...

and they may be primarily activating (mGlur1/5) or primarily inhibitory (mGlur2/3 and mGlur4/6/7/8). Ionotropic receptors tend to be quicker in relaying...

Metabotropic glutamate receptors (mGluR) InterPro: IPR000162 mGluR1 (GRM1) mGluR2 (GRM2) mGluR3 (GRM3) mGluR4 (GRM4) mGluR5 (GRM5) mGluR6 (GRM6) mGluR7 (GRM7)...

to be regulated by metabotropic glutamate receptors. Golgi cells possess mGluR2 receptors, and when these receptors are activated, an inward rectifier K...

modulator for group II of the metabotropic glutamate receptors (mGluR2/3), being equipotent at mGluR2 and mGluR3 but without activity at other mGluR subtypes...

ADX-71149, also known as JNJ-40411813 and JNJ-mGluR2-PAM, is a selective positive allosteric modulator of the mGlu2 receptor. It is being studied by Addex...

1002/glia.20798. PMID 18985735. S2CID 3222131. Bellesi M, Conti F (2010). "The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse...

inhibitor/NSAID – migraine [97] LY-2300559 – metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator and cysteinyl leukotriene receptor 1 (CysLTR1)...

subunit, which causes an upregulation of Metabotropic Glutamate Receptor 2 (mGluR2). This is most likely part of its antidepressant effect. Peripheral neuropathy:...

found that addicted rats display a prolonged and persistent impairment in mGluR2/3-dependent Long-Term Depression. Despite exposure to the same self-administration...

GABAB1δ, GABAB2, GABAA-rho Glutamatergic: NMDA, AMPA, Kainate, mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, mGluR6, mGluR7 Glycinergic: Glycine Histaminergic:...

selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterization and study of this receptor...

selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and has been useful in the study of this receptor subfamily. Ma D, Tian...

open-label study comparing it with lithium NA Increases the expression of mGluR2 and GAD67 via histone deacetylase (HDAC) inhibition. Glutamatergic agents...

Su R (March 2024). "Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling...

as a potent agonist of the NMDA and group I (mGluR1 and mGluR5) and II (mGluR2 and mGluR3) metabotropic glutamate receptors. It is inactive at group III...

group-selective agonist for the group II metabotropic glutamate receptors (mGluR2/3). It has potent neuroprotective and anticonvulsant effects in animal studies...

(Zhang and Marek, 2008), agonists and positive allosteric modulators of mGluR2 (metabotropic glutamate receptor 2) (Benneyworth et al., 2007), and selective...

PMID 36932180. This group has also reported that a heterodimeric complex between mGluR2 metabotropic glutamate and 5-HT2A receptors may be responsible for these...

complex range of interactions with the 5-HT1A, GABAA, adenosine A1, AMPA, mGluR2/3, mGlu5, and OX2 receptors. In the rat cerebellum, the protein has also...