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MICAL3
Identifiers
Aliases	MICAL3, MICAL-3, microtubule associated monooxygenase, calponin and LIM domain containing 3
External IDs	OMIM: 608882; MGI: 2442733; GeneCards: MICAL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D88
Enzyme activity
Gene location (Human)
Chr.	Chromosome 22 (human)
End	18,024,561 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	121,130,999 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right uterine tube; ; right hemisphere of cerebellum; ; apex of heart; ; body of uterus; ; smooth muscle tissue; ; epithelium of colon; ; muscle layer of sigmoid colon; ; left testis; ; left uterine tube;
	Top expressed in
	cumulus cell; ; lip; ; zygote; ; superior frontal gyrus; ; primary visual cortex; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; tail of embryo; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	monooxygenase activity; oxidoreductase activity; actin binding; FAD binding; metal ion binding; protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;
Cellular component	plasma membrane; cytoskeleton; nucleus; nucleoplasm; cytoplasm; cytosol; spindle; cell cortex; midbody; cell projection;
Biological process	actin filament depolymerization; cytoskeleton organization; exocytosis; cell cycle; cell division;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57553
	194401
	ENSG00000243156
	ENSMUSG00000051586
	Q7RTP6
	Q8CJ19
	NM_001122731; NM_001136004; NM_015241; NM_020793
	NM_001270475; NM_153396
	NP_001116203; NP_001129476; NP_056056
	NP_001257404; NP_700445
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated monoxygenase, calponin and LIM domain containing 3, also known as MICAL3, is a human gene.^[5]

Function

Along with two other Rab proteins, Rab6 and Rab8, MICAL3 work together in the process of docking and fusing of vesicles that are involved in exocytosis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243156 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051586 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MICAL3 microtubule associated monoxygenase, calponin and LIM domain containing 3".
^ Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, et al. (June 2011). "Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers". Current Biology. 21 (11): 967–974. Bibcode:2011CBio...21..967G. doi:10.1016/j.cub.2011.04.030. PMID 21596566. S2CID 7950950.

Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, et al. (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–364. doi:10.1093/dnares/5.6.355. PMID 10048485.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, et al. (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (June 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Fischer J, Weide T, Barnekow A (March 2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochemical and Biophysical Research Communications. 328 (2): 415–423. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000243156 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051586 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MICAL3 microtubule associated monoxygenase, calponin and LIM domain containing 3".

[6] Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, et al. (June 2011). "Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers". Current Biology. 21 (11): 967–974. Bibcode:2011CBio...21..967G. doi:10.1016/j.cub.2011.04.030. PMID 21596566. S2CID 7950950.

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MICAL3

Function

References

Further reading

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