ML domain
| ML domain | |||||||
|---|---|---|---|---|---|---|---|
 X-ray structure of Der p 2, the major house dust mite allergen | |||||||
| Identifiers | |||||||
| Symbol | E1_DerP2_DerF2 | ||||||
| Pfam | PF02221 | ||||||
| InterPro | IPR003172 | ||||||
| SCOP2 | 1a9v / SCOPe / SUPFAM | ||||||
| OPM superfamily | 91 | ||||||
| OPM protein | 1nep | ||||||
| CDD | cd00912 | ||||||
| |||||||
The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins:
- Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes.[1]
- House dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus.[2]
Human proteins containing this domain
References
- ^ Lobel P, Stock AM, Friedland N, Liou HL (2003). "Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2512–2517. Bibcode:2003PNAS..100.2512F. doi:10.1073/pnas.0437840100. PMC 151372. PMID 12591954.
- ^ Kristensen O, Kastrup JS, Skov LK, Gajhede M, Larsen JN, Johannessen BR, Bolwig C, Spangfort M, Lund K (2005). "Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity". FEBS Lett. 579 (5): 1208–12. Bibcode:2005FEBSL.579.1208J. doi:10.1016/j.febslet.2004.11.115. PMID 15710415. S2CID 30079878.
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