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MSRB2
Identifiers
Aliases	MSRB2, CBS-1, CBS1, MSRB, PILB, CGI-131, methionine sulfoxide reductase B2
External IDs	OMIM: 613782; MGI: 1923717; GeneCards: MSRB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L1U
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	23,122,013 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	19,399,787 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; apex of heart; ; vena cava; ; left ventricle; ; right auricle of heart; ; Skeletal muscle tissue of rectus abdominis; ; muscle of arm; ; biceps brachii; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; right kidney; ; cardiac muscles; ; granulocyte; ; right ventricle; ; lumbar spinal ganglion; ; proximal tubule; ; cervix; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; oxidoreductase activity; actin binding; zinc ion binding; metal ion binding; peptide-methionine (R)-S-oxide reductase activity; L-methionine-(R)-S-oxide reductase activity;
Cellular component	cytosol; mitochondrion;
Biological process	actin filament polymerization; response to oxidative stress; protein repair; regulation of transcription, DNA-templated; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22921
	76467
	ENSG00000148450
	ENSMUSG00000023094
	Q9Y3D2
	Q78J03
	NM_012228
	NM_029619
	NP_036360
	NP_083895
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene.^[5]^[6]^[7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.
^ Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.
^ "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Jung S, Hansel A, Kasperczyk H, et al. (2002). "Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1". FEBS Lett. 527 (1–3): 91–4. doi:10.1016/S0014-5793(02)03171-X. PMID 12220640. S2CID 2170229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
Picot CR, Perichon M, Cintrat JC, et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts". FEBS Lett. 558 (1–3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519. S2CID 32573388.
Hansel A, Jung S, Hoshi T, Heinemann SH (2004). "A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1". Redox Rep. 8 (6): 384–8. doi:10.1179/135100003225003429. PMID 14980072.
Schallreuter KU, Rübsam K, Chavan B, et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8749308-5] Escribano J, Ortego J, Coca-Prados M (Jan 1997). "Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins". J Biochem. 118 (5): 921–31. doi:10.1093/jb/118.5.921. PMID 8749308.

[pmid10375640-6] Huang W, Escribano J, Sarfarazi M, Coca-Prados M (Aug 1999). "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases". Gene. 233 (1–2): 233–40. doi:10.1016/S0378-1119(99)00131-6. PMID 10375640.

[entrez-7] "Entrez Gene: MSRB2 methionine sulfoxide reductase B2".

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MSRB2

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