Rhue guest-starred in dozens of television series, beginning with Cheyenne (1955). She played the spouse of the character portrayed by Ricardo Montalbán in a 1960 episode of Bonanza, "Day of Reckoning". That year, she also played the title role of Marian Ames in the Perry Mason episode "The Case of the Wayward Wife" and appeared in Route 66 Season 3 Episode 9.
Later in the 1960s, her appearances included Stagecoach West (1961), Rawhide (1963), The Defenders (1965) in "Whipping Boy" as Christine Knox and the classic Star Trek episode "Space Seed" (1967) where she once again appeared opposite Ricardo Montalbán (who played Khan Noonien Singh) playing his love interest Lt. Marla McGivers.[5]
In the early 1960s, Rhue was injured in an automobile accident that resulted in lost teeth and a cut lower lip. She was hospitalized before returning to acting.[7]
In 1977, Rhue was diagnosed with multiple sclerosis.[3] She continued to work, including a role in Days of Our Lives, but by 1985, Rhue's legs had become so weak from the multiple sclerosis that she could only get around by wheelchair.[3] Once becoming a wheelchair user, Rhue described feelings of fear and anxiety over being unable to land on-screen work in the entertainment industry for a period of 11 months. Regarding the matter, she was quoted as stating, "It became apparent that I would have to invent a giant accident to explain the wheelchair or start telling the truth."[3]
Despite being reliant on a wheelchair, Rhue managed to resume her entertainment career and was praised by media outlets for not allowing her health issues to disrupt her career. She played intermittent roles that did not require her to walk or stand, sometimes incorporating the wheelchair as part of the character. For example, she played a wheelchair-using ballistics expert on the CBS police-based legal drama, Houston Knights.[3] She also played a judge role in the scripted court show, Trial by Jury, lasting only the 1989–90 television season. She performed the role in a wheelchair, unseen to viewers as she presided from the judge's bench. Her part as a female judge was uncharacteristic for court shows, the genre dominated by men performing the judge role to that point.[1] She also performed a recurring role in Murder, She Wrote, said to be her last television role.[3][10]Angela Lansbury created a role for her when she heard that Rhue was at risk of losing her health insurance because she could no longer work enough hours.[3]
Contrary to rumors, her illness apparently had nothing to do with her not reprising the Star Trek role of Lt. Marla McGivers in the film Star Trek II: The Wrath of Khan (1982). At the time of the film's production start in late 1981, Rhue was still mobile and appearing in television roles, but hiding her diagnosis for fear of it impacting her career. Director Nicholas Meyer stated that he wrote McGivers out of his drafts of the film (with a line referencing the character's death) in order to give the Khan character additional motivation for seeking vengeance.[11]
In 1991, in her last movie, she played a wheelchair-using character in the made for television thriller A Mother's Justice.
(1) Season 6 Episode 2: "Seal of the Confessional" (1989) (2) Season 10 Episode 3: "The Legacy of Borbey House" (1993) (3) Season 10 Episode 21: "Wheel of Death" (1994) (4) Season 12 Episode 5: "Home Care" (1995) (5) Season 12 Episode 14: "Murder on Tempo" (1996)
^ abTerrace, Vincent (2011). Encyclopedia of Television Shows, 1925 through 2010 (2nd ed.). Jefferson, N.C.: McFarland & Company, Inc., Publishers. p. 129. ISBN978-0-7864-6477-7.