Takimoto began to consider a career in MMA after attending Pride 28 on Oct. 31, 2004 and seeing his friends and fellow judoka have success in the sport.[4] He announced on Dec. 7, 2004 that he would make his debut at Pride Shockwave 2004 against any fighter at any weight, as long as it was a "non-judo fighter."[4] He got his wish and made his debut vs. former SumoMaegashiraHenry Miller, winning via unanimous decision. He outlanded Miller almost 2-to-1 in significant strikes and took him down twice despite being significantly outweighed.[5] He fought for Pride six times in his career, posting a 3-3 record with the organization.[6] His victories came against the aforementioned Miller, fellow judoka Dong-Sik Yoon and Taekwondo expert Zelg Galešić.[6]
After Pride was disbanded in 2007, Takimoto earned the biggest victory of his MMA career, a split decision win over former UFC Middleweight ChampionMurilo Bustamante at Yarennoka on Dec. 31, 2007. He then joined the Sengoku Raiden Championship and fought four times with the organization. Takimoto was expected to participate in ASTRA, the farewell event for Hidehiko Yoshida on April 25, 2010.[7] However, he pulled out of the event and announced his retirement alongside Yoshida.[8]