Manasa Varanasi was born in Hyderabad to Ravi Sankar and Shailaja.[2] She moved to Malaysia at a young age due to her father's work and attended the Global Indian International School and completed her grade 10 there. Later she returned to India, and completed her intermediate then studied computer science at the Vasavi College of Engineering in Hyderabad. After graduating with a computer science degree, she began work as a financial information exchange analyst at FactSet, in Hyderabad.[3] She won the Miss Fresher title in the first year of her college.[citation needed]
Varanasi advocated strengthening child protection laws in India for her beauty with a purpose project. She also spoken about, "We Can", an awareness campaign against sexual abuse of children.[5][6][7]