He was born in Rousse (modern-day Ruse, Bulgaria), at that time subject of the Ottoman Empire, as a son of Mardiros Mârzayan and his wife, Mamilia Oglu, daughter of Hamum Oglu. A grain merchant, he amassed considerable wealth, and was rumored at the time to be the wealthiest man in the Balkans. In 1803, he was awarded the boyar rank of paharnic by Constantine Ypsilanti, Prince of Wallachia.
Towards the end of his life, he retired to his estate of Hîncești, where his son later built a manor house.
Manuc died in an accident in 1817, and was buried in the Armenian Church in Chișinău.
Personal life
Manuc-Bei married two times. His first wife was daughter of a rich Armenian merchant, whom he married in 1786. It is not recorded that there were any children born out of this marriage. In 1794, he married secondly Maria Harutyun (d. 17 September 1828), daughter of Hagi Harutyun. Together, they had two sons and four daughters:
Prince Murad (in documents Murat, Ivan, John) (1810-1893), married Countess Elena Davidovna Delyanova (1821-1870), sister of Count Ivan Delyanov:
Princess Maria (b. 1842)
Princess Ekaterina (1845-1920), married on 9 July 1881 with an Italian senator, Pietro L. Marquis Schedoni
Princess Olga (b. 1854-1920), married Count Bonifacius von Hatzfeld-Trachenberg (1854-1921)
Prince Grigore Grisha (1855-1902), was infatuated with Natalie Keșco, but instead of him, she married her cousin King Milan I of Serbia, Grigore died unmarried
Princess Mariam (in documents Maria) (d. 22 February 1822)
Princess Pemba (in documents Kaniane, Keiani, Gaiane, Gayrana), (d. 3 February 3 1824), married on 6 February 1820 Yakov Avitisyan, later changed family name to Melikterabov
Princess Gadara (in documents Gadiria, Gatera, Ecaterina) (1806-1880), married Christopher Lazarev (1789-1871), son of Joachim Lazarevich Lazarev (1743-1826), founder of the Institute of Oriental Languages Lazarev in Moscow and nephew of CountIvan Lazarevich Lazarev
Neagu Djuvara, Între Orient și Occident. Țările române la începutul epocii moderne ("Between Orient and Occident. The Romanian lands at the beginning of the modern era"), Humanitas, Bucharest, 1995, pp. 169, 287, 348–349
Constantin C. Giurescu, Istoria Bucureștilor. Din cele mai vechi timpuri pînă în zilele noastre ("History of Bucharest. From the earliest times to this day"), Editura Pentru Literatură, Bucharest, 1966, pp. 270–271.