In the 2015 regional election, after Tosi was sidelined by the federal party, Lanzarin made her comeback and was elected to the Regional Council from Zaia's personal list in the province of Vicenza.[7] After the election, Zaia, who had been re-elected President, appointed her regional minister of Social Affairs[8] in his second government. In 2019, she was additionally appointed regional minister of Health, after Luca Coletto resigned to become under-secretary of Health.[9]
In the 2020 regional election Lanzarin was re-elected to the Regional Council from the province of Vicenza. Subsequently, she was re-appointed minister of Health and Social Affairs in Zaia's third government.[10]