American cancer researcher and developmental biologist
Maria Jasin (born 1956) is a developmental biologist at the Memorial Sloan Kettering Cancer Center . She is known for studying homologous recombination , a method in which double-strand breaks in DNA strands are repaired , and for discovering the role of BRCA1 and BRCA2 in cancers .
Jasin was born in 1956 in Detroit , Michigan . Her father was from present-day Slovakia , while the family of her Canada -born mother was from today's Iraq . After her mother died, Jasin's father relocated the family to south Florida . Jasin and her older sister went to Florida Atlantic University for undergraduate studies, where she graduated with a BSc .[ 2] [ 3]
Jasin received her PhD in 1984 from the Massachusetts Institute of Technology under the supervision of Paul Schimmel .[ 2] Switzerland as a postdoctoral fellow at the University of Zurich for a year, and then returned to the United States as a postdoctoral fellow at Stanford University until 1990.[ 4]
In 1990, Jasin joined the Memorial Sloan Kettering Cancer Center (MSKCC) and Cornell University as an assistant professor and Frederick R. Adler Chair for Junior Faculty (until 1993).[ 4] [ 5] associate professor in 1996 and full professor and William E. Snee Chair in 2000.[ 4] [ 5]
Currently, she leads her own research group at the Developmental Biology Program in MSKCC,[ 6] Weill Cornell Graduate School of Medical Sciences .[ 7] Breast Cancer Research Foundation since 2017.[ 8]
Research
Jasin's research focuses on homologous recombination . She showed in 1994 that expressing a restriction enzyme that recognizes DNA sequences uncommon in the target genome , also known as a rare-cutting restriction enzyme , can generate DNA double strand breaks (DSBs) at specific locations, allowing for targeted genome editing .[ 9] [ 10]
The next year, in separate reports, Jasin's group discovered that BRCA1 [ 11] XRCC3 [ 12] BRCA2 is also required for homologous recombination.[ 13] cancers .[ 14]
Honors and awards
References
^ Jasin, Maria (1984). Gene deletions and point mutations which define functional domains in alanine tRNA synthetase . Retrieved July 13, 2023 . ^ a b "Autobiography of Maria Jasin" . Shaw Prize . p. July 13, 2023. Archived from the original on July 13, 2023. Retrieved July 13, 2023 .^ Sylvestri, Brittany (April 29, 2021). "FAU Honors 2021 Hall of Fame Inductees along with Distinguished Alumni" . Florida Atlantic University . Archived from the original on June 13, 2023. Retrieved June 13, 2023 . ^ a b c d "Maria Jasin" . Shaw Prize. Archived from the original on July 13, 2023. Retrieved July 13, 2023 .^ a b "Prof. Maria Jasin" (PDF) . NATURA, občianske združenie. Archived from the original (PDF) on July 30, 2023. Retrieved July 30, 2023 .^ "The Maria Jasin Lab" . Memorial Sloan Kettering Cancer Center . Archived from the original on July 30, 2023. Retrieved July 30, 2023 .^ "Maria Jasin" . Weill Cornell Graduate School of Medical Sciences . Archived from the original on July 30, 2023. Retrieved July 30, 2023 .^ "Maria Jasin, PhD" . Breast Cancer Research Foundation . Archived from the original on July 30, 2023. Retrieved July 30, 2023 .^ Rouet, Philippe; Smih, Fatima; Jasin, Maria (1994). "Introduction of Double-Strand Breaks into the Genome of Mouse Cells by Expression of a Rare-Cutting Endonuclease" . Molecular and Cellular Biology 14 (12): 8096– 8106. doi :10.1128/mcb.14.12.8096-8106.1994 . PMC 359348 PMID 7969147 . ^ Richardson, Christine; Moynahan, Mary Ellen; Jasin, Maria (1998). "Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations" . Genes & Development 12 (24): 3831– 3842. doi :10.1101/gad.12.24.3831 PMC 317271 PMID 9869637 . ^ Moynahan, Mary Ellen; Chiu, Joanne W.; Koller, Beverly H.; Jasin, Maria (1999). "Brca1 Controls Homology-Directed DNA Repair" . Molecular Cell 4 (4): 511– 518. doi :10.1016/S1097-2765(00)80202-6 PMID 10549283 . ^ Pierce, Andrew J.; Johnson, Roger D.; Thompson, Larry H.; Jasin, Maria (1999). "XRCC3 promotes homology-directed repair of DNA damage in mammalian cells" . Genes & Development . 13 (20): 2633– 2638. doi :10.1101/gad.13.20.2633 PMC 317094 PMID 10541549 . ^ Moynahan, Mary Ellen; Pierce, Andrew J.; Jasin, Maria (2001). "BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks" . Molecular Cell . 7 (2): 263– 272. doi :10.1016/s1097-2765(01)00174-5 PMID 11239455 . ^ Szewczak, Lara (2017). "A Conversation with Maria Jasin" . Cold Spring Harbor Symposia on Quantitative Biology 82 : 400– 402. doi :10.1101/sqb.2017.82.035345 PMID 29743335 . Archived from the original on August 7, 2023. Retrieved August 7, 2023 . ^ "Protecting the Genome by Homologous Recombination" . Mendel Lectures . Archived from the original on August 1, 2023. Retrieved August 1, 2023 .^ "Maria Jasin" . National Academy of Sciences . Archived from the original on July 31, 2023. Retrieved July 31, 2023 .^ "Dr. Maria Jasin" . National Academy of Medicine . Archived from the original on August 7, 2023. Retrieved August 7, 2023 .^ "Maria Jasin" . American Academy of Arts and Sciences . Archived from the original on July 13, 2023. Retrieved July 13, 2023 .^ "Maria Jasin, PhD" . American Association for Cancer Research . Archived from the original on August 1, 2023. Retrieved August 1, 2023 .^ "Dr. Maria Jasin" . American Philosophical Society . Archived from the original on July 31, 2023. Retrieved July 31, 2023 .
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