Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.
Pharmacology
In vitro study shows that maslinic acid inhibitsserine proteases, key enzymes necessary for the spread of HIV within an individual's body.[1] It also has in vitroantiproliferative effects on colon cancer cells.[2] Maslinic acid increases EAAT2 (GLT-1) glutamate reuptake and may reduce glutamatergic toxicity in rats.[3] Additionally, maslinic acid serves as a glycogen phosphorylase inhibitor in mouse liver,[4][5] as evidenced by increased glycogen accumulation in rainbow trout liver.[6]
Clinical significance
Maslinic acid demonstrates antioxidant capabilities against oxygen and nitrogen reactive species.[7][8] It also exhibits a suppressive impact on proinflammatory cytokines like TNF-α and IL-6 in murine macrophages.[8] These mechanisms could contribute to enhanced protein synthesis, growth rates, and joint support.[9] Maslinic acid has been shown to improve muscle mass in the elderly when combined with resistance exercise.[10]
^Márquez Martín A, De La Puerta Vázquez R, Fernández-Arche A, Ruiz-Gutiérrez V (2006). "Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages". Free Radical Research. 40 (3): 295–302. doi:10.1080/10715760500467935. ISSN1071-5762. PMID16484046.
^Wen X, Sun H, Liu J, Wu G, Zhang L, Wu X, Ni P (2005-11-15). "Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases". Bioorganic & Medicinal Chemistry Letters. 15 (22): 4944–4948. doi:10.1016/j.bmcl.2005.08.026. ISSN0960-894X. PMID16169219.
^ abMontilla MP, Agil A, Navarro MC, Jiménez MI, García-Granados A, Parra A, Cabo MM (2003). "Antioxidant Activity of Maslinic Acid, a Triterpene Derivative Obtained from Olea europaea". Planta Medica. 69 (5): 472–474. doi:10.1055/s-2003-39698. ISSN0032-0943. PMID12802735.
