MiRTarBase

miRTarBase
Content
DescriptionExperimentally validated microRNA-target interactions (MTIs).
Data types
captured		miRNA-target interactions
Contact
Research center
AuthorsHsien-Da Huang and colleagues
Release date
  • v1.0: 2013
  • v10.0: 2024
Access
Websitehttp://mirtarbase.cuhk.edu.cn
Download URLhttp://mirtarbase.cuhk.edu.cn/php/download.php
Miscellaneous
Version10.0

miRTarBase [1] is a curated database of MicroRNA-Target Interactions. Generally, the collected MTIs are validated experimentally by reporter assay, western blot, microarray and next-generation sequencing experiments.

The first version of the miRTarBase has accumulated more than fifty thousand miRNA-target interactions (MTIs), which are collected by manually surveying pertinent literature after data mining of the text systematically to filter research articles related to functional studies of miRNAs. miRTarBase has been regularly updated since the original release in 2011.[2][3][4][5][6] The most recent update (miRTarBase 2025 / version 10.0) reports over 3,817,550 experimentally validated miRNA–target interactions curated from 13,690 articles.[7]

miRTarBase improvements

See also

References

  1. ^ Hsu SD, Lin FM, Wu WY, Liang C, Huang WC, Chan WL, Tsai WT, Chen GZ, Lee CJ, Chiu CM, Chien CH, Wu MC, Huang CY, Tsou AP, Huang HD (2011). "miRTarBase: a database curates experimentally validated microRNA-target interactions". Nucleic Acids Research. 39 (suppl_1): D163-9. doi:10.1093/nar/gkq1107. PMC 3013699. PMID 21071411.
  2. ^ Hsu, SD; Tseng, YT; Shrestha, S; Lin, YL; Khaleel, A; Chou, CH; Chu, CF; Huang, HY; Lin, CM; Ho, SY; Jian, TY; Lin, FM; Chang, TH; Weng, SL; Liao, KW; Liao, IE; Liu, CC; Huang, HD (January 2014). "miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions". Nucleic Acids Research. 42 (suppl_1): D78-85. doi:10.1093/nar/gkt1266. PMC 3965058. PMID 24304892.
  3. ^ Chou, CH; Chang, NW; Shrestha, S; Hsu, SD; Lin, YL; Lee, WH; Yang, CD; Hong, HC; Wei, TY; Tu, SJ; Tsai, TR; Ho, SY; Jian, TY; Wu, HY; Chen, PR; Lin, NC; Huang, HT; Yang, TL; Pai, CY; Tai, CS; Chen, WL; Huang, CY; Liu, CC; Weng, SL; Liao, KW; Hsu, WL; Huang, HD (4 January 2016). "miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database". Nucleic Acids Research. 44 (D1): D239-47. doi:10.1093/nar/gkv1258. PMC 7145596. PMID 26590260.
  4. ^ Chou, CH; Shrestha, S; Yang, CD; Chang, NW; Lin, YL; Liao, KW; Huang, WC; Sun, TH; Tu, SJ; Lee, WH; Chiew, MY; Tai, CS; Wei, TY; Tsai, TR; Huang, HT; Wang, CY; Wu, HY; Ho, SY; Chen, PR; Chuang, CH; Hsieh, PJ; Wu, YS; Chen, WL; Li, MJ; Wu, YC; Huang, XY; Ng, FL; Buddhakosai, W; Huang, PC; Lan, KC; Huang, CY; Weng, SL; Cheng, YN; Liang, C; Hsu, WL; Huang, HD (4 January 2018). "miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions". Nucleic Acids Research. 46 (D1): D296–D302. doi:10.1093/nar/gkx1067. PMC 5753222. PMID 29126174.
  5. ^ Huang, HY; Lin, YC; Li, J; Huang, KY; Shrestha, S; Hong, HC; Tang, Y; Chen, YG; Jin, CN; Yu, Y; Xu, JT; Li, YM; Cai, XX; Zhou, ZY; Chen, XH; Pei, YY; Hu, L; Su, JJ; Cui, SD; Wang, F; Xie, YY; Ding, SY; Luo, MF; Chou, CH; Chang, NW; Chen, KW; Cheng, YH; Wan, XH; Hsu, WL; Lee, TY; Wei, FX; Huang, HD (8 January 2020). "miRTarBase 2020: updates to the experimentally validated microRNA-target interaction database". Nucleic Acids Research. 48 (D1): D148–D154. doi:10.1093/nar/gkz896. PMC 7145596. PMID 31647101.
  6. ^ Huang, HY; Lin, YC; Cui, S; Huang, Y; Tang, Y; Xu, J; Bao, J; Li, Y; Wen, J; Zuo, H; Wang, W; Li, J; Ni, J; Ruan, Y; Li, L; Chen, Y; Xie, Y; Zhu, Z; Cai, X; Chen, X; Yao, L; Chen, Y; Luo, Y; LuXu, S; Luo, M; Chiu, CM; Ma, K; Zhu, L; Cheng, GJ; Bai, C; Chiang, YC; Wang, L; Wei, F; Lee, TY; Huang, HD (7 January 2022). "miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions". Nucleic Acids Research. 50 (D1): D222–D230. doi:10.1093/nar/gkab1079. PMC 8728135. PMID 34850920.
  7. ^ Cui, S; Yu, S; Huang, HY; Lin, YC; Huang, Y; Zhang, B; Xiao, J; Zuo, H; Wang, J; Li, Z; Li, G; Ma, J; Chen, B; Zhang, H; Fu, J; Wang, L; Huang, HD (6 January 2025). "miRTarBase 2025: updates to the collection of experimentally validated microRNA-target interactions". Nucleic Acids Research. 53 (D1): D147–D156. doi:10.1093/nar/gkae1072. PMC 11701613. PMID 39578692.
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